What is Serrapeptase?

It’s been called “The Miracle Enzyme.” Serrapeptase is an enzyme derived from silkworms. The serratia peptidase works in the blood, digesting non-living tissues. It has anti-inflammatory effects and can help prevent blood clots. Serrapeptase is a proteolytic (protein destroying) enzyme from bacteria native to the digestive system of silkworms. It is the enzyme responsible for dissolving a silkworm’s cocoon.

NOTE:  This page is an extremely thorough guide to serrapeptase.  If you are looking for some specific information about serrapeptase, simply hit Ctrl + F on your keyboard, then type your keyword search term into the search box that appears on your screen (if you’re using Firefox as your browser, look in the bottom left corner for the search box) .  That will help you locate where that information appears on this page.

Serrapeptase has been found to have the ability to liquefy mucus and reduce bacterial biofilms (reducing bacteria’s ability to stick to surfaces and each other). This means serrapeptase may be able to reduce phlegm buildup, nasal discharge, lung symptoms of cystic fibrosis and help other compounds fight bacteria. Additional research is needed to confirm these effects.  Researcher Robert Redfern can also be an authority to seek out for further information.

“Serrapeptase is an enzyme which  “eats” away dead tissue etc. This will cause aches however the aches are short lived and depending on where the dead tissues as well as blockages in the arteries are depends on where the aches will be. The aches are a sign that the serrapeptase is working. If you do not have any aches then it isn’t doing anything for you and you are wasting your money.”

Fibrinolytic systemic enzymes dissolve excess fibrin that forms in various organs and tissues during the normal wound healing process. Excess fibrin can form in the kidneys (leading to high blood pressure), carotid arteries (stroke), muscles (Fibromyalgia, Carpal Tunnel Syndrome), the brain (senility), and the respiratory/pulmonary tracts (sinusitis, fluid retention and inflammation). The strongest fibrin-eating enzyme is serrapeptase, a natural anti-inflammatory.

The serrapeptase brand I have seen recommended the most, is Doctors Best (available at iHerb) . This also happens to be the brand used in some of the studies, so that’s good enough for me!  Needless to say, its the brand I personally use as well and I’ve had good results.  Doctors Best also makes a high potency formula, but as of yet I have not personally tried that one.

Serrapeptase is often used along with Nattokinase, another miracle enzyme supplement – the two tend to work synergystically when used together, meaning each one helps the other work even better. So if you are interested in Serrapeptase, you should learn more about “Natto” as well.

I buy all my supplements online at iHerb.com – they truly have the best prices you’ll find anywhere (and excellent selection on all major brands) – do your own price checking and you’ll see!

Serrapeptase is made from an enzyme that removes blockages in the body that impede healing and optimal health. You can think of it as a pipe cleaner or bulldozer for the body that dissolves arterial plaque, blood clots, cysts, and scar tissue while banishing pain and inflammation.

* Helps reduce pain and inflammation effectively without harmful side effects
* Safe for both people and pets
* Enerex is the original serratia peptidase product
* Proven to help with the following conditions: rheumatoid arthritis, fibrocystic breast disease, edema, carpal tunnel syndrome, post-operative swelling, chronic sinusitis.

Goes Well With Antibiotics (reduces biofilm on bacteria, and thus enhances the ability of antibiotics to act upon bacteria).

DO NOT TAKE IF YOU ARE ON BLOOD THINNERS. May cause stomach upset in persons with digestive issues.

Due to potential fibrolytic activity, caution should be taken when taking serrapeptase with moderately potent blood thinners (Fish Oil) and should not be paired with more potent blood thinners (Clopidogrel, Warfarin, Aspirin)

Serrapeptase is an enzyme which  “eats” away dead tissue etc. This will cause aches however the aches are short lived and depending on where the dead tissues as well as blockages in the arteries are depends on where the aches will be. The aches are a sign that the serrapeptase is working. If you do not have any aches then it isn’t doing anything for you and you are wasting your money.

Serrapeptase has been used successfully for over 30 years in Europe and Asia to reduce pain, inflammation and excess mucus secretion. More than 40 clinical studies have shown beneficial effects. Serrapeptase digests non-living tissue, blood clots, cysts, and arterial plaque and inflammation in all forms. Serrapeptase dissolves blood clots and causes varicose veins to shrink or diminish.

When consumed in unprotected tablets or capsules, the enzyme is destroyed by acid in the stomach, so its important to only use enteric-coated caplets to enable the enzyme to pass through the stomach unchanged, and be absorbed in the intestine.

Serratia peptidase or serrapeptase is a proteolytic enzyme produced by the Serratia bacterium which lives in the intestine of the silkworm. When the silkworm is ready to emerge from it’s cocoon it produces an enzyme that dissolves that very hard shell so that this delicate little creature can enter into a new world. This enzyme is naturally processed commercially today through fermentation. Serrapeptase digests inflammation and benign cysts and helps clear plaque from arteries. It is widely used for pain since it is antinflammatory. I have also found that if I feel a cold coming on and take 3 of these several times during the day it doesn’t develop and clears up.  It is said to reduce scars and alleviate allergies.  May help to prevent heart attack and strokes.

Some people take as many as four 60,000 SU capsules per day (60,000SU = 30 mg., average is 3 times per day .  Must be taken on an empty stomach for effectiveness – this means 1/2 hour before meals, or 2 hours after. Check with The Serrapeptase Guy (Robert Redfern, Nutritionalist) for assistance on dosing your serrapeptase.

If you get loose stools when taking this, reduce the dosage.

Real People’s Experiences With Serrepeptase

NOTE:  Below you will find a tremendous amount of information from real users about how serrapeptase has helped them with many different health conditions.   If you are looking for some specific information about serrapeptase, simply hit Ctrl + F on your keyboard, then type your keyword search term into the search box that appears on your screen (if you’re using Firefox as your browser, look in the bottom left corner for the search box) .  That will help you locate where the specific information you’re looking for appears on this page.

A friend was diagnosed as having dementia. I recommended Serrapeptase. Six months later, after an all-day schedule of tests at a geriatric clinic by three doctors, they could find no trace of any dementia! NIH has conducted some seminal research on these issues: http://www.ncbi.nlm.nih.gov/pubmed/23821590

At this point (age 83), with no further need for any specific cure, I look upon 120K Serrapeptase as a “longevity pill.” It removes plaque from the blood vessels, thus mitigating the risk of heart attack and stroke due to high cholesterol. Serrapeptase prevents blood clots, thus mitigating the risk of heart attack and stroke from this source. Cancer cells develop a thick protein coat to prevent attack by the immune system. Serrapeptase removes this protein coat, thus opening the way for the immune system to attack the cancer cells. Recent research by the National Institute of Health (NIH) shows the efficacy of Serrapeptase for removing plaque in the brain (beta amyloid), and is therefore a promising treatment for Alzheimer’s and dementia. Serrapeptase, in conjunction with Nattokinese, provides relief from COPD and emphysema. Having such a broad spectrum of benefits, Serrapeptase is truly a pill for the ages.

I was diagnosed with Peyronie’s about a month ago. After doing research, it was evident that medical science offered limited options for its cure, and even those options had mixed results. Among natural remedies, Serrapeptase seemed to show promise, and Doctor’s Best brand appeared to show better results than others. So I decided to give it a try. After one month of use (3 capsules of 40,000 units one hour before breakfast daily), the plaque is gone completely (the appointment I made a month ago with a urologist is still a month away:)) I did not notice any obvious side effects.

I could not believe how fast my broken tail bone healed after I started taking this. Anyone who as ever suffered through this know it takes months and years to heal. I took quite a bit more than recommended, (9)/day, but in two weeks time I am sitting and not in pain!!! This is my second time for breaking my tail bone so I can compare it directly to before. I am still amazed that it doesn’t hurt. I quit taking it and the pain hasn’t come back. This is amazing. Far exceeded my expectation.

I don’t yet know how the Doctor’s Best brand compares with more expensive brands such as those recommended by The Serrapeptase Guy, but it was actually his website that had this brand (Doctor’s Best) as one of the alternative products in the same class that had a decent potency rating.

I noticed several people had expressed concern about the enteric coating (which contains plastic) and I contacted the company to ask what the new coating, “Serrateric” had in it. Here is their reply, verbatim: “Doctor’s Best has recently improved it Serrapeptase formula by removed the enteric coating and using Serrateric™. Serrateric™ is a proprietary non-GMO natural coating-free acid protection system. Serrateric™ is a combination of approved food additives (self-affirmed GRAS) that work to provide gastric protection for pH sensitive enzymes without the need for additional coating. Doctor’s Best Serrapeptase does not contain phthalates.”

I looked up the studies on pubmed.gov. There are rare reports of people, usually elderly, developing pneumonia induced by this medication. The initial symptoms are shortness of breath, coughing and muscle pain. It seems to develop within two weeks of starting to take this. Please watch out for these symptoms if you are taking this.

My wife said these have helped to remove cellulite from her legs.

I’m hoping it will help with my Fibro. I do feel like I have more energy since using this product 4 months. Also I don’t feel the need to snack as much and have lost 10 pounds which was an unexpected bonus.

This stuff is like magic for clogged arteries!!! I’ve got a few years experience with Serrapeptase. Specifically this brand, as it’s heads and shoulders above anything else I tried. I have seen this clean veins out so many times it doesn’t even phase me anymore. At first it really seems like magic, but now that the shock has worn off, it’s just that good! I have a couple examples: I had an elderly client (a regular) who started having dark purple/black congestion in the toes with pain. I started him on a bottle of this and within a month all the toes returned to normal color and pain was gone. Another elderly man, who I see a couple times a year, came to me. He had had a triple bypass surgery in his recent medical history. He complained about his feet being cold… so did his wife…. so I recommended he try this. He called me a week or so later from his home a few states away. He told me he had taken only 12 capsules and his feet were so warm it was almost like they were on fire. He had a check-up with his cardiologist a week later, who sent word back through the client that he wanted more info on this as well as he couldn’t believe the change in this man in the short time since he had seen him last. I had a young Amish woman who was in a car/buggy wreck. Compound fracture in lower leg. She was left with alot of painful scar tissue. One month on the Serrapeptase lightened the scarring and removed the soreness she had. I have many more examples like this. This stuff works people! That being said… I have found a big issue: if you are on blood thinners DO NOT TAKE THIS! This will thin the blood out a little bit and if used with a blood thinner it can lead to bleeding under the skin. BE WARNED. Also some people who have digestive issues can’t tolerate it. It’s a powerful supplement, treat it as such. I’ve only ever needed 3 bottles max on any one person.

A few people have reported strange dreams when taking Serapeptase.

Only adverse effect I noticed is the first 2 or 3 days at night I did feel a very slight pain in the center of my chest. From what I read that could be from you arteries clearing That went away the 3rd or 4th day.

I also take Vitamin K-2. every other day with Vitamin D-3. I think the Serra. removes the soft dead stuff clogging our joints and arteries. and the K-2 with D-2 removes the calcium and puts it where it belongs, like teeth and bones.

I have had inexplicable chest pain EVERY SINGLE DAY for well over 4 years. I have had cardiac stress tests, a heart scan, a cardiac cath, endoscopy, etc. I was told I have esophageal spasms, GERD, anxiety…whatever. Being a former cardiac RN and having angina with MI and CVA type symptoms is terrifying. I have tried everything and had resorted to Atenolol and Imipramine. I also suspected that the chest pain was caused from a lack of oxygen to my heart in the SMALLER vessels around the heart which is enough to cause pain, but not enough for muscle damage.

I suffer from migraines and read that serrapeptase was a great natural anti-inflammatory so I decided to give it a try. In the 2 months that I’ve been using this, I’ve had no migraines and 2 very very very minor headaches. I equate that all to these enzyme. It’s great, couldn’t recommend it enough. A friends father now uses it for his knee and has noticed a tremendous increase in mobility. Worth noting that at first I took this pill once a day in the morning on an empty stomach. I’ve since cut down to taking it once every 3-4 days, still keeping off the pesky headaches & migraines

I was very pleasantly surprised to discover that it has a HUGE effect on sinus inflammation, which has always been a problem for me (Oklahoma allergies. Sigh.) My need for Sudafed has greatly abated. It’s worth taking for that alone.

Very efrfective in treating symtoms of Lymes Disease.

Doctor said this cleans the blood.

Heart patient. Has kept my arteries clean for 3 years.

They contain enzymes which wander through the arteries gobbling up any plaque or debris, preventing a heart attack or stroke.

Stroke runs in my family, and serrapeptase is supposed to help clear scar tissue and thin your blood.

My husband snores badly. I read that serrapeptase helps with sinus problem, which my husband happens to have, so I started to give it to him, just 2 pills in the morning on empty stomach. After 2 weeks on it, the snoring sound were less noticeable. If he takes it continuously, he doesn’t snores at all.

I think it has caused me to shed a few pounds too-a very good thing.

I took 3 tablets 3 times a day on an empty stomach and am keeping the should pain at bay with no allergic reaction. Im am thrilled to have found this. This is a miracle for me. I am amazed at the pain relief.

Product is working great, have more movement than I have had for years.

We have been giving serrapeptase (1/2 hr before or 2hrs after food) to our large 9yo dog to help him recover from cruciate ligament surgery. We also give a natural raw meat and veg diet plus vitamins, minerals and fish oil. The vet was astonished at how quickly our dog was recovering from surgery and said he felt he was at least 2 weeks ahead of where he expected him to be. After over-exerting and stiffening up, having some pain, I doubled the dose of serrapeptase giving it 3 times in 24hrs and it definitely made a wonderful difference getting him happily mobile again very quickly. Serrapeptase is something we will continue to purchase for our dog to maintain his good results. My son requires surgery soon and serrapeptase will be part of his recovery plan.

I bought this product as an experiment to see if it would make any difference to the symptoms of my condition (MS). I have only been taking it for a couple of weeks, so I can’t say for sure if it has done anything yet, but I will be keeping a careful eye

I’ve been taking from 5 to 9 capsules a day. One injury example is I got squashed in the chest and something cracked but I wasn’t sore. A day later it got quite sore. Every time I took a breath I could feel it but I could still sleep ok at night. First 2 weeks of taking serrapeptase I didn’t notice much change but another 2 weeks and it was about 50-80% better.

Serrapeptase has helped lower my high cholesterol. Also since I’m unable to take other pain killers it is the only thing that helps relieve arthritis.

I have found that my breathlessness, related to coronary heart disease, has been significantly reduced after three weeks. I have now gone on to a maintenance level doses. I am absolutely convinced that this produce, Serrapeptase, has contributed greatly to reducing the symptoms of my CHD.

Product has helped, but need to know it is important to take with a probiotic.

It’s supposed to help dissolve protein deposits in the bloodstream and is good for the heart. And since I’ve had a clot I figure it cant hurt and I haven’t had a clot since..Be sure to take with no food in stomach or its useless. I take 1 pill with plenty of water before bed.

Lowered my blood pressure about 30/15 points. Was usually around 135/85 to 140/90 and now I’m 105/70 to 115/75. Not sure how effective this brand is for me on a per unit basis. I have to take a lot of it to get an effect. Usually at least 6 pills a day and will likely go to 9 or more a day soon. Eventually tapering back down to a maintenance dosage.  (Using the 120 SU dosage).

I have suffered from very severe sinus allergies forever. No medicine off the shelf even in high doses will do much good and only Flonase spray will help although not always. Flonase has only recently become non-prescription. In the past I have tried every single allergy medicine on the store shelves. I usually only got about 2% help and 98% side effects. However, for the first time in many decades I am mostly free of allergies after taking this. For sinus relief this stuff is better than anything I know.

I was told no more Viagra will be needed, and for someone who cannot take testestorone due to prostate issues, this has proven to clear the ‘pipes’ and the morning wake up is up once more. LOVE IT! Really effective in short time.

For me, it cured my high blood pressure while years of prescription medicine failed to help.

I have been taking this to help with Angina pain that I have been experiencing for a month now. I have to say that after taking it for a week my pain has substantially subsided. I still have the occasional pain but it is not nearly as pronounced.

I recommend this anti-inflammatory product to anyone experiencing chronic muscle and abdominal pain.

My bad cholesterol went way down after taking this for only 6 weeks. I take 6 a day. Robert Redfern says you can take 9 a day. It can’t hurt you. It helps with SO many different things. Cleared out my moms carotid arteries.  120,000 SU)

I fortunately have never suffered from kidney stones, but my sister used to get them quite frequently. She would be incapacitated for at least three days, exhausted from the pain. A couple of years ago, she had another kidney stone and had bunkered down in her bed to survive the next few days. I then recommended that she take 120,000 units of Serrapeptase 4-6x per day, with at least an hour’s space before or after food. That evening, her pain was already significantly reduced, and she was better by the next day!! She got back to her normal routine within 24 hours. Can you believe that?!

Well now, I’ve been able to recently confirm that this stuff works. A guy friend of mine posted on Facebook that he had a kidney stone (diagnosed at the doctor). He was given prescription level pain meds. I told him about Serrapeptase and he was off of his pain meds in less than 24 hours! And it’s been said that kidney stones for men can cause about as much pain as childbirth in women. So that says something!

Serrapeptase is a proteolytic enzyme (breaks down proteins). It comes from the enzymes silkworms use to get themselves out of their cocoon. When taken orally, Serrapeptase helps to break down unnecessary proteins in the body. A lot of people have had success reducing scar tissue or speeding up the healing process when takin this product.It also is highly anti-inflammatory, helping to reduce pain and inflammation in the body. In fact, some people take this instead of Advil or Tylenol. But now we know that it can also gently break kidney stones so that they are eliminated from the body easily.

Serrapeptase has been used to treat chronic sinusitis, carpal tunnel syndrome, sprains and torn ligaments, fibrocystic breast disease, ovarian cysts, ear, nose and throat infections, fibromyalgia, varicose veins, emphysema, asthma, bronchitis, migraines (vascular), Inflammatory Bowel Diseases (IBD) including Crohn’s, colitis and cystitis, enlarged prostate, pain, and postoperative inflammation. Some researchers believe Serrapeptase can play an important role in arterial plaque (hardening of the arteries) prevention and removal.

Other clinical trials support Serrapeptase’s ability to relieve the problems associated with ear, nose, and throat infection, anosmia (loss of smell), nasal obstruction, laryngitis, difficulty in swallowing, often in just 3-4 days. Physicians assessed efficacy of treatment as excellent or good for 97.3 percent of patients treated with Serrapeptase compared with only 21.9 percent of those treated with a placebo. One anecdotal report indicated that Serrapeptase ended years of snoring literally overnight.

I’m 40 years old and have had joint pain in my knees since highschool. I also have frequent lower back pain and some stiffness. After one week taking serrapeptase, the joint pain is virtually gone and the back pain and stiffness is improving! I’ve been telling everybody about this because it’s very significant to me. My blood pressure has also lowered and normalized (without any change in my diet or exercise routine). I am also sleeping better and seem to have more energy. I can’t say that all of these effects are directly related to the serrapeptase, but it’s the only change I’ve made in my routine so far.

Fibrinolytic (Clot Busting) Action: Hans A. Nieper, M.D., an internist from Hannover, Germany, studied the effects of Serrapeptase on plaque accumulations in the arteries. The formation of plaque involves deposits of fatty substances, cholesterol, cellular waste products, calcium and fibrin (a clotting material in the blood) on the inner lining of the arteries. Excessive plaque results in partial or complete blockage of the blood’s flow through an artery, resulting in arteriosclerosis, and potentially a stroke or heart attack. The evidence to support Serrapeptase’s role in preventing plaque build-up is anecdotal. Still, further studies are called for in this area as Nieper’s research indicated that the protein-dissolving action of Serrapeptase will gradually break down atherosclerotic plaques.

According to Dr. Nieper, 30,000 I.U. of Serrapetase per day for 12 to 18 months is sufficient to remove fibrous blockages from constricted coronary arteries, as confirmed in many of his patients by ultrasound examination.

When combined with Nattokinase, another amazing fibrinolytic enzyme, and other natural products including omega 3 fatty acids and Terminalia Arjuna, natural health practitioners have a powerful method of improving cardiovascular health without the side effects of drugs.

If you suffer from inflammatory diseases, rheumatoid arthritis, osteoarthritis, sinusitis, carpal tunnel syndrome, snoring, fibrocystic breast disease, ovarian cysts, fibromyalgia, varicose veins, Inflammatory Bowel Disease, migraine headaches, enlarged prostate, tennis elbow, lung problems, arteriosclerosis, edema (swelling), pain, or cardiovascular plaque build up, Serrapeptase may provide the relief you’ve been looking for, without the side effects of NSAIDs and COX2 enzyme inhibiting drugs.

I started by using low potency Dr’s best Serrapeptase and was quite amazed at the results. First my usual agonizing fibromyalgia pains cleared up by about 90% in around a month. Second a cyst on my finger shrunk to 10% of its size and third, a small growth on my inner thigh disappeared.

Upon discovering that my carotid arteries were 40 percent blocked, I began taking 120,000 SEU of Serrapetase daily. After about six weeks, it became apparent that Serrapeptase was effectively curing my Peyronie’s disease! This was a totally unexpected result, but it made sense. The ability of Serrapeptase to dissolve scar tissue was doing the “impossible.” Medical science offers no cure for Peyronie’s disease other than surgery, which is never more than partially successful. Serrapeptase will do what medical science cannot, and do it relatively fast. At last, there is a cure for Peyronie’s disease!

i found out about serrapeptase and read all i can and found that it helps animals too. was talking to my neighbor, who said she had to make an appointment for her dog Corona, to be put to sleep, the dog has cancer of the mouth, stopped eating and stopped moving. i told her that i heard that serrapeptase might help animals too, so i went home and got her three high potency capsules, and told her to give her one a day and see if it helps. the NEXT DAY my neighbor came knocking on my door, to tell me that Corona started eating is not only up, but prancing on her tippy toes, which she hasn’t done in a couple years. needless to say that I gave her a few more to hold her over till her order came in the mail. it is over a month now and Corona is eating more and more and has a quality of life that she hadn’t had for a while. I am so proud that I tell everyone I see about SERRAPEPTASE, and how i saved my neighbors dog’s life.
It is worth noting that Serrapeptase amplifies the effects of blood thinners, including aspirin. I was taking 325 mg of aspirin daily. Even with the aspirin, my blood coagulation rate was 10 percent faster than normal. I happened to get a small cut on my hand, and it bled profusely, indicating that the Serrapeptase does indeed amplify the effects of blood thinners. I immediately switched to 81 mg of aspirin. About two weeks later, I got a small puncture on a finger tip, and it, too, bled profusely. So I stopped taking aspirin all together. I plan to get some blood work, coagulation tests, etc. to determine exactly what is going on in the blood stream. It may turn out that the optimum therapy to minimize the danger of heart attack and stroke may be the normal daily aspirin routine, coupled with periodic clearing of the blood vessels with Serrapeptase, during which time no aspirin is taken.

For two years I was back and forth at the doctor’s office because of high cholesterol. I was determined not to take Lipotor. So I kept buying time, asking for another two months to get my diet and exercise right. It never happened until I started taking 2 of these each morning on an empty stomach. Amazingly enough, after about 6 weeks of taking the serrapeptase, I received a positive reading on my cholesterol.

I take it because I have heart disease. Research indicates that it has significant cardiac benefits.

With two or three capsules i can remove my headache.

It cleared my sinuses right away. I could breathe again and Ive had sinus polyps all my life with chronic sinusitus.

After 6/7 weeks of use I can’t feel the fiber cyst in my breast. I truly believe their gone. I must say I am quite impressed. Try it you can’t go wrong.

I’ve used this product quite successfully for inflammation and circulation. My naturopath recommended it for blood clots that had swollen my legs after an accident a few years ago.

Taking this is the way to keep healthy and prevent heart attacks and strokes as these capsules wander through your arteries gobbling up any plaque.

I originally ordered this product because I read it could help fibroids. I have a large fibroid and I want to avoid surgery if at all possible. I don’t know yet if it is helping the fibroid but it seems like I’m starting to see results in other ways. I had a lot of pain in my feet from walking on a hospital floor for almost 2 months, while my mom was hospitalised. When I first get up in the morning, the pain is really awful. About 1 week after starting the serrapeptase, my feet didn’t seem to hurt quite as much. I’m hoping that they will get better and better as I continue taking the serrapeptase. I also have noticed that I seem to breathe better and I am not suffering from sinus congestion like I was before.

It makes quite a difference in my digestive system–no feeling of bloating any more…amazing!


My Canadian doctor here in New Mexico recommended 60,000 IU (International Units) on an empty stomach twice a day. Taken as directed, at least in my experience, has helped lessen the fatigue and improved my stamina–and going without it for a couple of weeks, due to a family emergency, I really noticed the difference.


Sinus infections are awful for me. My ears were getting so filled that my left ear couldnt hear. Over 2 months of being sick, I did some research, went back on what I had left of this product. Within a day, both ears starting popping, draining started to occur, and within a couple more days, I was able to hear out of both ears properly, and sinus/ear draining is still going on.  (Supposed to take 120 3x day for ear infections).

I have two herinated discs in lower back. Taking one cap a day leaves me virtually pain free. When I don’t take one I have significant pain

fantastic for opening the sinuses of a chronically congested sinus sufferer. Opens sinuses so you can breathe all night long while you are sleeping. Something I haven’t been able to do for years until trying this product.

Serrapeptase is proteolytic enzyme. Proteolytic enzymes are enzymes that break down proteins into their smallest elements. When taken on an empty stomach, proteolytic enzymes pass through the stomach or intestine lining and enter the circulatory system, they circulate throughout the body. I take Serrapeptase before meals and it helps me greatly to alleviate pain resulting from the traumatic inflammation.

Serrapeptase has allowed me to get off my allergy medications.

Effective if taken on an empty stomach, serrapeptase is designed to breakdown fibrin proteins including blood proteins, viruses and bacteria.

Have had a lipoma cyst on my chest for years that has been removed surgically, but keeps coming back. Since taking 3 a day, the cyst is considerably down in size and no pressure now when I bend over. Hopefully it has cleaned my arteries also.

I had what seemed to be an enlarged vein (aneurysm or aneurysm) on my forehead, where I bumped my head. This has reduced its size.

Took this for a few days and my nose bled a little for almost 3 weeks, especially when sneezing. Serrapeptase thins blood, I wonder if there is a relation. It might be just me, but I never get nose bleed normally, so I though it was strange.

I have tried another brand of Serrapeptase and it didn’t even come close to this one. Also the eccentric coating on the caps helps it to get better absorbed into my system. (Doctors Best brand)

I ordered this for my wife to replace prednizone. She has suffered with a bad back for years with no help from the doctors. The Serrapeptase has given her her life back again.

This product totally helps minor pain, and also has been proven to reduce and eliminate inflammation all throughout your body (even in your brain.

I used to take “DANZEN” brand of serrapeptase to treat inflammation whenever I have a gout attack. Whenever, the pain arises, I need to take a dosage of 30,000 i.u for 2-3 times and the pain/inflammation gone. I switch to Doctor Best as it is much cheaper. Recently, I have another gout attack. After taking 80,000 i.u per day for 5 consecutive days, the pain/inflammation is still there. Hence, I have doubt whether each veggie cap really contain 40,000 i.u. I will be switching back to the brand “DANZEN”

This is working very well for me! My arthritic knees and lower body fibromyalgia has cleared up by 60% in about a week, and is continuing to improve. I recommend it highly.

I only take one a day & experienced less muscle & joint pain. Do not take with food as it may upset your stomach, but wait a hour after or a hour before eating. I have neck pain & upper back discomfort & these work.

I’ve been talking this for several months now and it’s worked wonders. My neck pain and stiffness are greatly reduced. In fact, they are usually completely relieved.

REMEMBER, you must take this product AWAY from food for it to work effectively. Week One – I took three in the morning and three at bedtime;

If I started a headache, I’d pop two of them and the headache would scamper off. Better than analgesics and it has no negative side effects, just good ones

I had some shoulder joint pain for some time.I was given a cortisone injection into the joint itself and put on Naproxen 500mg for 2weeks.This failed to yield any improvement.The Serrapeptase however,resolved the pain completely.

I’ve been taking this for 2 months for uterine fibroids, and the results are FANTASTIC!!! A very LARGE fibroid is now almost half its original size, and all of the symptoms have diminished exponentially, too! The dosage and enteric form match that used in medical research

I had a slight tightness in my chest with mucus production for years and that is all gone alongside nasal congestion.My occasional allergies when indoors are no more and a wart that I developed is slowly breaking a part to reveal healthier tissue. I take it with ginger tea to reduce stomach upset.

I have also gone down a pant size since staarting to take them.

I started out taking multiple caps 3 times day, then reduced dosage. A pleasant side effect was about 12 lb weight loss over 3 months. When I stopped taking it the weight came back on

Normalized a messy bowel in less than week

serrapeptase is a powerful anti-inflammatory useful in many problems–chronic pain–cysts–clots–plaque–it’s an amazing product!

This was recommended to me by my sister who was taking NSAIDs regularly for her back pain. she started taking this and has been able to stop taking ibuprofen. I tried it for the knee pain I sometimes get after aerobic workouts and think this is a keeper. Very good results.

This product realy helped eliminate 90% of my morning pain and stiffness. I take three capsules first thing each morning.

Months after my bypass surgery I continued to have “stable” angina. The doctors didn’t seem concerned but I sure was so,I started searching the Web for natural treatments for angina. I came across Serrapeptase. I have been using it for over 2 years and I am ANGINA FREE! It wasn’t immediate relief but after a few months of taking it(and I’m not one to continue with things if I don’t see immediate results – but because of the studies I saw I knew I should stick with it) I realized the angina was gone and I didn’t have the all-over body aches and pain I used to have, either.

Can give it to pets also for arthritis and aches and pains of old age.

This product is truly extraordinary. It is working on too many previous problems for me to even list. My sciatica is GONE, as is my IBS, my blood pressure is the lowest I have had as an adult, and I have only been taking this for two weeks.

Not sure why this works, but I use it in place of advil for back pain, menstrual cramps, etc. It is awesome.

After 4 months of physical therapy and alot of motrin I found this product. Most of my neck pain seemd to melt away the first week I began taking it.

This enzyme eats away any inflammation! I used it for arthritis and for asthma and it works like a charm.

Serrapeptase is typically sold in pharmacy at 20,000unit strength under brand names like Danzen. This is 40,000unit strength per capsule. It has affinity for mucus membrane. Very effective in addressing inflammatory response in the throat and sinuses, either due to allergies or pathogenic attack.

This product eliminated my lower back stiffness and pain by the end of the bottle. That pain had been troubling me for about five years. UPDATE: Two years later and still no sign of pain. I’m 59 and as flexible now as I’ve ever been. I continue taking it on a daily basis to be sure I stay that way.

Awsome product, especially when taken with Doctor’s Best nattokinase. Wonderful for arthritis or circulatory problems. An all natural solution to a growing health issue.


Greatly reduced my blood pressure.

I have to say I couldn’t believe all the hype that I saw surrounding it but it does a lot of the things that are listed out there in cyberspace. I’ve had some nerve trouble in my arm since a bout of phlebitis from a bad IV for a few months but after only a few doses the shaking weakness and pain have completely cleared up. Also the Pancreatic cyst that my doctor found recently shrank from 3 cm to 1 cm in a matter of 3 weeks. It’s still hard to believe how much this stuff actually does.

This has helped with post-workout muscle pain. Also great for flu symptoms.

It reduces my back pain tremendously. I take the maximum recommended dosage.

After using it for a month now I can say that I am feeling and moving at least 25% better than without it.Being more active I’ve even lost 12 pounds.

I am weary of the cases of pulmonary affections claimed to be caused by serrapeptase and closely monitoring that department. With that aside, I have pain around one vertebrae that sometimes wakes me up during the night, diagnosed to be due to my scoliosis, and found this product to be one of the very few remedies that truly helps with this kind of pain.

It took about two weeks of taking 2 a day 2x a day for the pain to subside. I could bearly walk until I took these pills. The pain is 95% gone.  I also took Nattokinase with these.

Worked very well to resolve my sinus issues and to reduce seasonal allergies. Unfortunately it aggravated my pre-existing high blood pressure and I had to discontinue. Blood pressure quickly returned to previous levels after stopping serrapepatase use.


I’ve taken it on an empty stomach and with food and the result is the same: upset stomach later, sometimes the next day. Add to that cold sweats, queasiness, and fitful sleep. At first I wasn’t sure it was the serrapeptase but again and again it only happens after I take it. I’ve tried 1-4 caps at a time but as little as one cap causes these symptoms. This morning I took one cap along with nattokinese (which I’ve taken for over a year so I can exclude that) and was back in bed for a fitful nap that lasted 4 hours. I was abnormally tired and my stomach hurt. In fact, I’ve taken more anti-acid stomach remedies in the last month of use than in the previous year. Stranger yet, a few days ago after taking this, my stomach hurt well into the next day until I had a bowel movement. After that, it was like the clouds lifted and the clammy, queasy feeling and upset stomach vanished. So it seemed to have this effect well down the digestive tract. I bought this to replace ibuprofen and thought it might help with overall health as reported in the many glowing reviews. I haven’t experienced less pain or any noticable benefits.

I was informed I have 2 blocked fallopian tubes
The first 3 days of taking this product a huge mucus plug came out! I looked online to see blocked tubes look like with scar tissue and mucus and the mucus plug I passed look exactly like the gross pictures of tubes filled with gunk. Thank god this product worked so fast I will continue to take it and do a follow up HSG in 4 months

I wanted to take it for a good while before reporting any results. I’m happy to say that within a couple of weeks of taking serrapeptase, a hypothyroid-related leg rash cleared up completely. In the past I’ve had to use steroidal cream to clear it up. The cream left a scar that sunburns easily. The serrapeptase cleared it up and seems to be working on the scar as well. I haven’t had another rash flare-up since. The other big, big plus is that my cycle is normalizing. It had shortened considerably, so I was having my period every 23 days – not fun. This had been going on for several years. I tried prescription progesterone creams to no avail. Just recently, it’s back on track at 28 days.

I’d been developing poor circulation in my legs over several years. It had become so severe that I felt like I was walking on two numb clubs. Additionally I’d been having minor bouts of angina and weakness while walking. This all began disappearing in just a few days after taking three 120,000 unit capsules of serrapeptase, evenly spaced, per day, one hour before eating or two hours after eating. I did this for a week and my legs are returning to normal plus I have not experienced any further angina. Additionally much of the numbness in my extremities has disappeared. Numerous websites provide information about serrapeptase and its use by oncologist Dr. Hans Alfred Nieper of Hannover, Germany before his death in 1998. Serrapeptase has been found to dissolve arterial plaque quickly, safely, and efficiently plus it is quite economic

This has gotten rid of my batholyn cyst two times. I’ve had the surgery twice, and now i’m hoping these can keep seeing me through.

I’d been taking serrapeptase at a lower dose for over a year to treat adhesions related to gastric bypass surgery. Six months ago I switched to this higher dosage. Last month I had a miscarriage at 6.5 weeks. My doctor wanted to do a D&C immediately but I wanted to let things pass naturally to avoid surgery and scar tissue. After a week of no bleeding or discharge I agreed to surgery out of fear of infection. After surgery my OB told me I had very little tissue remaining. She expected to find more based on my initial ultrasound but she said my body had already dissolved and resorbed a good amount of tissue. They tested what was removed and it was confirmed to be embryonic. I now think the serrapeptase had already started cleaning out my uterus. In hindsight I should have waited another week and asked for another ultrasound to avoid surgery. I had stopped the serrapeptase three days prior to surgery and resumed two days after in order to avoid increased bleeding (read that somewhere online). I increased my dosage to two capsules twice daily along with nattokinase to prevent any scar tissue that may affect a future pregnancy.

I had stent put in my heart in 2011 and since then had chest pain and nothing showed up on EKG or stress test and doctor said only option is to back and do angioplasty.I heard about serrapeptase and started with 40,000 units in march-april 2013 and within a week my chest pain have gone away.Now i have moved to stronger 120,000 units to keep the good work,i normally take them in the middle of the night when i get up to go to the bathroom as i am empty stomach at that time.I would recommend this to anyone who is having angina pain.

The first purchased I’ve made was the 40,000 IU strength, and it worked well for me. I just didn’t like taking it 2 to 3 times a day. I have since ordered the 120,000 IU. I take it once a day in the morning. This product does what it says it will do. I’ve had problems breathing throughout the day, and especially at night. I believe that I’ve had sinusitis (sinus inflammation and congestion), to some degree. It was pretty much constant throughout the day and especially at night. I never had a cold, but I’ve noticed that my sinuses were always (for a good portion of the day and night) congested. This product has helped relieve my issue. I also have very high cholesterol (390 points) so I’m excited to know that this is used for potential arteriosclerosis. I truly believe that this product helps to get the “gook” out of your body. What was proof for me is that I had recently donated blood. I found out that my blood pressure was at 114/70. Holy cow! It’s better than where it was when I was in high school. I can attribute it to this product, and I take Dr. Black’s, raw organic supplements, too. Since the “gook” is being removed, apparently, my chosen supplements appear to work much better, as well. I’m not a doctor, but I’m not a fool, either. This is some good stuff! I don’t trust fully our Western medical practices. A Dr. would have recommended a pharmaceutical drug, complete with many side affects, as my option. No, thank you! I will stick with something natural.

Started taking for something else and it ended up getting rid of my asthma. I’ve been taking it everyday for over 6 months now and have no plan to stop.

Great for biofilm removal and removing toxins. It worked for me, although I don’t use it anymore, because I don’t need to. I finally got rid of all the candida, SIBO and other bugs that were causing severe dysbiosis in my body for years. I’m not just cured – I’m actually healthier now than before. And just when I was starting to think it couldn’t be done – I’d be suffering from this miserable condition for the rest of my life….but no. It can be done, so just wanted to pass that message on to all those that are suffering from biofilm and other issues due to major microbiota imbalances.

The first week in January I woke up from a nap with a terrible eye floater. It looked like a big black spider swirling directly in the center of my field of vision in my right eye.
I got an appointment with my Optometrist the same day.
He said there was nothing he could do. Except recommend laser surgery, or some other expensive, high risk procedure.
I got on the Internet and quickly discovered Serrapeptase. Which ordered from Amazon.
They recommended 40,000 units, three or four times a day on an empty stomach. I got the 120,000 SPUs and just took two of them when I first woke up. In about a week the color started fading from the “floater”. I’m About 1/3rd of the was through my second bottle, and the floater is about 99% gone. I have to really look for it to find it. Mission accomplished.

Stunned….shocked…..happily surprised! Even after reading so many reviews here for this very product, and reading about the scar tissue dissolving effects of this product, I’m still surprised. I did not get this product for scar tissue dissolution. I got this product to break down cancerous tumor fibrin and biofilm mucous. My tumor is still shrinking (breast cancer diagnosis…no surgery, radiation, or chemo). Biofilm in the back of my throat is gone as well. But the clincher is this. I had a huge 45 year old scar from open heart surgery when I was almost 5 years old. I was one of the very first people to ever have open heart surgery as it was still *almost* experimental at the time (some people didn’t survive the surgery back in the late 60s when I had it). It saved my life (I was born with a hole in my aorta…mom smoked while pregnant). But the scar was pretty bad……I was always self-conscious about it, but learned to live with it, of course. I got this product, not knowing what to expect but curious from reading the reviews. Well, the scar is probably 60% improved at this point. My husband leaned forward while I was sitting on the couch to get a closer look at it. He goes, “Wooooowwwwww. That’s amazing!” We’ve been discussing how incredible the shrinking of the scar has been since I first noticed it. I’ve had weird, mushy, cysts on the underside of my wrist completely dissolve as well. This product is truly incredible. And for what it does? DIRT CHEAP. I plan on taking this product for quite a while and I’ll be curious as to how much of the scar tissue is dissolved eventually. Right now, I’m simply stunned at how good the scar looks after all of these years.

This cured my two year long bout of foot pain which wouldn’t allow me to go barefoot. Plantar facitis and heel spur pain ended before I finished the first bottle. I take two in the morning when I wake up and two before bed if I remember. I’m on my fourth bottle. I can not take the typical OTC pain killers and am a long time in recovery substance abuse person and also someone without health insurance so trips to the doctor aren’t in the budget. They honestly never did much for me anyway since I’ve been averse to “scripts” for three decades. The typical “wow I must be older than I realized” physical pains on awakening disappeared by the end of the 2nd bottle. I worked as an Operating Engineer for 20 years (retired now) and had 12 whiplashes in my life. Although I love chiropractors and visit one three or four times a year, and appreciate the occassional visit to an acupunturist, this bottle of magic is the most affordable option for me to live pain free. WTG little silkworms! Thank you for eating up all the fibrin in my *been rode hard and put up wet* 55 year old body.

My wife & I started taking this 5 months ago. I had an enlarged prostrate pain for 10 years, and had problems with trying to empty bladder. After 2 months I noticed better urine flow and no more enlarged prostrate pain. No side effects, my wife had hip pain for 20 some years, after two months pain subsided, now she is pain free. We did a lot of study on this before taking it. We are both 66 years old and are on no other medications. Always ask your doctor first if it is ok to start on any supplements. I tried everything for the prostrate problem in the last 10 years and nothing seemed to work. I gave up coffee which I love to drink because it made my problem worse. now I drink 2 cups in the morning and even an espresso every other day and does not bother me. We are very happy with this product.

I have chronic sinus congestion, and noticed this morning, to my surprise, that my breathing cleared up about 20 minutes after taking this product.

I was surprised by this effect, because I’ve taken serrapeptase before without noticing anything similar. When I took it in the past, I usually took one or two 40,000 SPU capsules (for a total dosage of 80,000 SPU). Today I took two 120,000 SPU capsules (for a total dosage of 240,000 SPU.) The larger dose is what appears to have made a difference.

I should mention that I was not taking serrapeptase alone. I took it in water along with some other enzymes, on an empty stomach. (I don’t take proteolytic enzymes with food, I take them an hour or so before eating.) I take the other enzymes regularly, but have not noticed them helping my breathing. It was the addition of serrapeptase that appears to have made a difference.

After noticing the clearer breathing, out of curiosity, I typed in “serrapeptase mucus” in my browser, and found some web pages and videos saying that others have experienced this effect. One Youtube video by John Gray talks specifically about the effects of serrapeptase on mucus and congestion. Just google the name of the video if you’d like to watch it: “Serrapeptase reduces inflammation and mucus in the body”


When I first heard about Serrapeptase I was skeptical. I googled it and saw positive reviews, so I decided to try it. I am so amazed at the pain relief, I can hardly believe it! I’ve been suffering with rheumatoid arthritis for years. I have not been able to do heavy work for about 10 years. I started taking Serrapeptase last Monday and already this week I was able to spend 6 hours scraping wallpaper on Wednesday and 2 hours shoveling snow on Saturday! No pain! This is truly amazing!


I was under the wrong impression this would help with cancer and breaking down the fibrin tumor casing.
When I started taking it, my mucus production increased and kept increasing to an uncomfortable level.
I thought it was detox symptoms, so I kept going. But then, I searched ncbi database and found out that serrapeptase makes neutrophil counts decrease. Well, I need all the white blood cells I can get to fight the cancer. So I am switching protease enzymes.

(Comment re above: This supplement is used in cancer treatments, along with cannabis oil. If the oil kills off to many cancer cells at once, it causes a herxing effect, which is very painful and also feels like the flu. This supplement rids the body of the excessive dead cells so that you don’t experience the herxing effects.)

I have been taking this product for almost 4 months now. I am 55 years old and have had arthritis and spinal stenosis which has caused severe sciatica pain for the last 15 years. I have not wanted to take prescription meds for pain and have tried everything imaginable. I have had pain to some degree every day for 15 years. This product has been the first thing to give me relief. I take three capsules every morning on an empty stomach. It didn’t work immediately but over time I noticed I was actually have some pain-free days which has been a miracle for me. I started out taking 1 capsule per day and slowly am up to 3 and I do believe this may be the correct dose for me. I think the dosage may vary from person to person. I am writing this review to hopefully help another person who has suffered with arthritis. I also have noticed that it has helped my sinus’s too. This product took some time for me but I am so glad that I waited it out and know now that it clearly works for me


I have been taking Serrapeptase now for a year my severe arthritis in my knees vanished. I have fibroids they have shrunk and am pain free from them. tried to stop taking the serrapeptase to see if anything would happen and after about a second week my pain and stiffness started to kreep up in my knees;i began taking it again and pain and stiffness went away 🙂 I’d rather take this everyday then pain medicine that would harm me.

I have taken these for years & cannot believe it’s taken so long to write a review. I am an athlete and also have endometriosis (have even had surgery to remove it). These pills are amazing. I have no cramping or uncomfortable feeling at all now. They work. I also feel relief in my knees as I assume scar tissue has gone away. No side effects at all. I occasionally stop taking them for a month but go back on when I feel symptoms returning which happens every time I stop

I started taking Serrapeptase about 6 months ago on the recommendation of a friend. I took just one capsule a day for two weeks, and noticed nothing. I upped my intake to two capsules a day, and stuck with it for another month and a half. Suddenly, I realized one day that I was pretty much pain free. Prior to this, my hands had become increasingly painful, and I was having problems opening jars and doing other household chores. With the Serrapeptase, it all went away gradually. I returned to normal, able to do whatever I needed or wanted to do. I decided after this experience that you have to play around a bit with this product to see what works for you. Those people who say that took it for 2 weeks and it didn’t work didn’t really give it a chance.

My husband had lower back pain for approx 3 years. Nothing would help including many prescriptions. I found this wonderful miracle online and within 3 weeks, back pain completely gone and never returned.

I was diagnosed with a thing called Mortens Neuroma and told the only way to fix this would be surgery. After surfing around on the net i got onto Serrapeptase and with all the write ups being positive I thought I would give them a go. The traditional “allow 3 months for them to get into your system” for me blew out of the door when after 3 weeks I started to feel some very a lot better. Mortens Neuroma is a kind of cyst that grew in between bones in my foot and gave me excruciating pain at certain times which made it very difficult to walk without a pronounced limp. Anyway after being on 3 Serrapeptase tablets per day, taken every night before going to bed, I can honestly say that 3 weeks from starting to take them I can walk without pain.


Anytime of recovery is sped up x 3 with taking this.

My mother and I started to take this to see if it would help keep the arteries clean. She had scans 2 years ago, and they are better, clearer now, and her cholesterol was perfect. My cholesterol is always high, but was much lower this time, and at 62, my artery scan shows no significant build up.


I’ve been taking Serrapeptase (4 caps twice a day) for over 2 months to get rid of a number of fatty tumors I have under the skin, and those tumors are now just a fraction of the size they were when I started taking the serrapeptase capsules. I have a friend at work that started taking it, and in 3 days she no longer needed to take a nasal spray for her blocked sinuses at bedtime. And her 85 yr old father with emphysema, after 4 days on serrapeptase, was breathing deeper and easier. My barber noticed after taking it for 1 week that a pain she had had in her leg for 15 yrs due to an ATV accident just went away. A co-worker who’s taken it for several months now said that the grinding in a rotator cuff injury in his shoulder is getting less and less. So this stuff does work. I currently have about a dozen friends now taking it. (40 su)


I’ve been taking 2 Serrapeptase capsules every morning (1st thing – empty stomach), for over three months. The first thing I noticed within a few weeks was decreased insomnia, after 6 wks – less joint pain, after 2 months – no more shortness of breath when going up stairs. Blood pressure has also gone down about 5 pts. Absolutely NO side effects.

I had a cyst under my arm that was the size of a marble, which has now almost gone away. Will review as I learn more.

I felt immediate results from the first dosage – 3 capsules relieved my wrist pain (carpal tunnel) and kept it away all day. Increased dosage to 6 caps and my sinuses have completely cleared up for the first time in 20 years! I have recommended this to friends who have seen similar results. One friend was suffering with severe back pain while taking 2 ibuprofen 5x/day. She started taking 6 capsules of Serrapeptase a day, and now her back pain is gone and her sinuses are clear. Another friend had shoulder pain for years, and 4 caps of Serrapeptase took care of that pain plus cleared up her sinuses.

Seems to be a positive for the digestive system. Smart to take to rid the body of inflammation pockets – which can be a precursor to cancer.



i have been taking serrapeptase for 6 months. i have only had to take pain killers twice in the past 6 months. i have arthritus, a hip replacement and both shoulders have been operated for rotator cuff injuries. i take two in the morning and two at night. i started out taking 8 a day for two months. the most amazing discovery was the fact i had little or no dental plaque. i hadnt had my teeth cleaned in 13 months and i dread that procedure because i have so much plaque. the only plaque i had was alittle bit on my bottom teeth. tnis is one of the most amazing herbs. i am 78 years old and feel wonderful.




This product is not only good for insect stings but its supposed to break up blood clots and clear up blood vessel blockages. Its probably good to take this along with Vitamin C if taking it for circulation.


This product has helped to reduce pelvic scar tissue from a previous surgery. I have had a great reduction in monthly endometrial pain that I was having previously. My monthly menstrual cramps have significantly been reduced as well.

Seems to be helping my husband’s memory without any negative side effects.

Recommended it to a friend whose dog had a blood clot and it fixed the problem. It does all it says.

I started to use it for my chronic sinusitis issues. It has been great. I will continue to use this product. I don’t get the buildup in my chest and nasal passages while actively taking this product. I have read a lot on this product and it is very helpful for the entire body in many different ways.

After 35 years of lower back pain, I’m pain free after 3 days of usage (3 pill a day).

I first started using Serrapeptase for Sinus issues approximately 7-years ago. I wnt from daily headaches to maybe 2 or 3 per year within a few weeks. Plus, it is cleaning my blood vessels!

I’ve been experiencing lower back pain overnight that wakes me up so it’s fairly uncomfortable. I decided to start to seriously take serrapeptase for this pain and also to help with extreme fatigue following an extended “cold” as well as continuing mucus issues. Within 3 days, the pain was gone, mucus was gone, an extremely bad scar almost gone, and energy returning on a 2 dose a day schedule. I’ve upped it to 4-6 and have been rewarded with enhanced digestion, tons of energy, clear sinuses and lungs, and hopefully the other internal benefits that this supplement is known for. All this within the first week of daily use. I wonder if the folks not getting results are taking serrapeptase on an empty stomach, as the bottle indicates.


I have always looked for help with my sinuses. This product has totally cleared my sinuses. People say I look more rested- my sinuses had always settled under my eyes , but not any more!I will never be without this product – it’s the bomb!I started by taking 2 before bedtime and noticed some results. Then I stepped it up and took 2 in the am and 2 in afternoon and 2 before bed.That did it. Just make sure you take them on empty stomach.

My orthopaedic surgeon told me that the medical establishment doesn’t think oral enzymes work, as the acid in the stomach is likely destroying them before they are absorbed.  However, personal experience would indicate otherwise.

I usually stick with the Nattokinase but have taken the Serrapeptase to help with my blood pressure with good results.

Great for arthritus and also for affecting the lining of the intestines.

I noticed a big swelling under my 1 year old dog Lion, it looked like it was blood clot or fluid, i have no money for vet but i cried like a baby and gave him 2 pills, in the morning at 7.15am i checked him nothing, serrapeptase is a miracle

Said to dissolve arterial plaque, and blood clots also reduce varicose veins. Personally; i can only attest to the varicose veins, that on my left leg are now barely noticeable. i took one cap 3 times a day of 40 iu for most of one bottle then now i only take one cap a day, feel better and my veins do too.

When Advil doesn’t work,this does.

Serrapeptase is a chemical taken from the silkworm. It is a commonly used drug (Takeda Chemical Industries) in Japan and Europe. In the U.S., serrapeptase is classified as a dietary supplement.

Serrapeptase is used for painful conditions including back pain, osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, carpel tunnel syndrome, migraine headache, and tension headache.

It is also used for conditions that involve pain and swelling (inflammation) including sinusitis, laryngitis, sore throat, ear infections, swelling after surgery, swelling of a vein with the formation of a blood clot (thrombophlebitis), and inflammatory bowel disease (IBD) including ulcerative colitis and Crohn’s disease.

Some people use serrapeptase for heart disease and “hardening of the arteries” (atherosclerosis).

Women use it for non-cancerous lumpy breasts (fibrocystic breast disease), and nursing mothers use it for breast pain caused by too much milk (breast engorgement).

Other uses include treatment of diabetes, leg ulcers, asthma, and pus accumulation (empyema).

How does it work?

Serrapeptase helps the body break down protein. This might help decrease inflammation and mucous.

Since little human research is available in the West, it is preferable to take breaks from use until we learn more about the full clinical effects. At this time we don’t have full knowledge of potential serrapeptase allergic reactions, side effects, cautions or dangers, and how it interacts with medicines and other supplements. We also don’t have a full understanding of which medical conditions it is most effective for.

Side Effects are extremely rare and unusual, but below are reports of some side effects people have experienced:

After taking one serrapeptase tablet on an empty stomach, eight hours later I experienced stomach upset and nausea which lasted for nearly 24 hours. Since this nausea could have been caused by something else, I waited a couple days before taking another pill.  The results were the same. My nausea was so bad that I was unable to eat my usual lunch.
This is the first report we have had of nausea and gastrointestinal symptoms associated with this enzyme.

After taking serrapeptase for approx. one week I developed a very disturbing deep and unusual cough while attending my college alumni homecoming weekend. The cough seriously irritated my lungs and bronchial tubes, and was uncomfortable enough that I left the campus a day earlier than planned. I had no other related symptoms of any kind, and I am not a smoker. I started investigating online to see and found research that said that an unusual form of pneumonia could develop in elderly users. I am in my middle 70’s. Since after a week to 10 days after stopping the pills, the cough slowly disappeared without any discernible after-effects.

One MD prescribed a low dose of prednisone (15 mg) for a several weeks for a diagnosis of polymyalgia rheumatica. My shoulders, and hips ached and especially after doing some light exercise. Because of the side effects of prednisone I read about (suppressed immune system), I contacted an alternative health care person who prescribed 6 caps containing 120, 000 units of enzymatic activity. The third night I had dull aching pain in my hips, lower back and knees along with extreme fatigue. I quit taking it on the fourth day and am feeling a little better.

I started taking 40,000 units serrapeptase twice daily to clean my arteries. After 3 weeks I noticed that my veins looked abnormal when I took a pill, but I thought it was just something temporary. One morning I woke up with a slight painful feeling in my right ankle. When I stood up I had a strange sensation in both of my legs, I could not really stand or walk, and my veins looked extremely large when I was standing. I stopped taking serrapeptase that morning, and since my condition did not improve for two days, I went to a vein doctor who examined me and said that I have varicose vein. I also see spider veins in the area under my ankles.

I have a really weak immune system and took 160,000 iu of serrapetase in one day. Followd the instructions on the bottle, 80,000 3 times a day. I I took the first pill and nothing happened.. but when I took the second I felt like I was going to die, my chest tightened, I couldn’t breath and felt so weak, I could hardly walk.

I have had a chat with my doctor. He said the risk with using this enzyme is that when it breaks up arterial plaque into smaller bits, then the loosened plague can make it’s way into smaller arteries and cause blockages. He also mentioned that if these smaller pieces end up moving into your brain then it can potentially cause a stroke. Please indicate if you are of a different opinion? I am really keen on using this product as a preventative measure, but obviously not at the risk of causing problems elsewhere.
A. I am not aware of any studies that have shown these medical problems to occur and I would be interested in reviewing such studies if your doctor can provide the references. – Ray Sahelien

I was taking serrapeptase on an empty stomach successfully for 3 months. It gave me surprising relief from inflammation-related pain (overuse injuries). Upon switching brands, it began to cause nausea and vomiting, up to 8 hours after taking it. I took a break for a couple of weeks, switched back to my previous brand, but after a week of taking it with no side effects, the vomiting began again. Apparently I have developed a sensitivity for this product? I cannot find any reference to this on the internet and am wondering if you have any information? I had been recommending serrapeptase to my friends, but now I am wondering if it is perhaps a dangerous product.
A. Perhaps the dosage needed is less than you require, and perhaps it is a good idea to not take it every day or to take 2 days off a week. Another option is to try it with a little bit of food in the stomach.

Q. As a few others have noted, I also stopped taking serrapeptase due to joint and muscle pain that made it painful to walk, move my arms….don’t know how long it will take to completely eliminate it from my system.

Q. Have heard good things about the use of serrapeptase for reducing inflammatory conditions in the body for various chronic conditions, for everything from arthritis to cancer. Should one stop using such a supplement before surgical or dental procedures and if so how far in advance. Since this is a proteolytic enzyme should one be careful about taking it with other digestive enzymes or blood thinners?
A.  It would be prudent to stop its use a week or so before surgery. Its interactions with other enzymes and blood thinners are not fully understood yet.

Q. I am a medical resident and have read your post about serrapeptase and there were several questions and comments about dosages. It is clear that many are taking dosages that are way too high and as such are causing some side effects, mainly muscle and joint pain. Let me remind you that one of or maybe the western medical pioneer of that enzyme Dr. Hans Nieper, used usually a dosage of 3 x 5mg per day. Beats the hell out of me how we in north America wound up with tablets of 10 to 15 times that dosage.

Serrapeptase dosage, amount to take
This natural enzyme is a relatively new supplements compared to vitamins A, B, C etc. The long term benefits and side effects are not yet fully understood. I prefer being cautious and erring on the side of taking less rather than more until several more years pass and I have a clearer understanding of the benefits and risks.

Alzheimer’s disease
Hum Exp Toxicol. 2013. Serrapeptase and nattokinase intervention for relieving Alzheimer’s disease pathophysiology in rat model. These enzymes may have a therapeutic application in the treatment of AD.

Chronic lung disease and mucus
Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease.
Respirology. 2003.
We investigated the effect of 30 mg/day on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of treatment, sputum weight in the morning, percentage solid component, viscosity and elasticity of sputum, sputum neutrophil count, frequency of coughing and frequency of expectoration significantly decreased.

Jaw pain and swelling after dental surgery
Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars.
Int J Oral Maxillofac Surg. 2008.
Twenty-four healthy individuals with symmetrically impacted mandibular third molars underwent surgical removal in a prospective, intra-individual, randomized, double-blind, cross-over study. Teeth were removed in 2 sessions by the same surgeon. At each session, one third molar was removed under local anaesthesia via a buccal osteotomy. All patients received a combination of either serrapeptase 5mg or placebo tablets and 1000 mg paracetamol tablets at either the 1st or 2nd operation in accordance with the randomization plan. There was a significant reduction in the extent of cheek swelling and pain intensity in the serrapeptase group at the 2nd, 3rd and 7th postoperative days, but no significant difference in mean maximal interincisal distance was found between the 2 groups.

Serrapeptase or serratiopeptidase research study
A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome.
J Assoc Physicians India. 1999.
Twenty patients with carpal tunnel syndrome were evaluated clinically. After baseline electrophysiological studies, these patients were given serrapeptase 10 mg twice daily with initial short course of nimesulide. Clinical and electrophysiological reassessment was done after 6 weeks. Sixty five percent of serrapeptase cases showed significant clinical improvement which was supported by improvement in electrophysiological parameters. Recurrence was reported in four cases. No significant side effect was observed. Serrapeptase therapy may proved to be a useful alternative mode of conservative treatment. Larger study may be further helpful to establish the role of serrapeptase in carpal tunnel syndrome. Serratiopeptidase therapy.

Intestinal absorption of serrapeptase in rats.
Biotechnol Appl Biochem. 1994.
Serrapeptase in the plasma was determined after its oral administration (100 mg/kg) to rats. The peak concentration was observed between 30 min and 2 h after administration. These results indicate that orally administered serrapeptase was absorbed from the intestinal tract and transferred into the circulation in an enzymically active form.

Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo.
University of Naples, Italy.
J Int Med Res. 1990.
The efficacy and tolerability of serrapeptase were evaluated in 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 4 days’ treatment significant symptom regression was observed in treated patients. There was also a significant reduction in symptoms after 8 days for patients in both treatment groups but the response was more marked in those patients receiving the active drug. It is concluded that serrapeptase has anti-inflammatory, anti-edemic and fibrinolytic activity and acts rapidly on localized inflammation.

A case of pneumonitis due to serrapeptase
Nihon Kyobu Shikkan Gakkai Zasshi. 1989.
A 69-year-old man was treated with serrapeptase for 16 days because of common cold, then fever, nonproductive cough and dyspnea developed and chest X-ray revealed diffuse fine granular shadows in bilateral lung fields. Once the administration was halted, symptoms, chest X-ray abnormalities and laboratory data improved markedly. Microscopic examination of transbronchial lung biopsy showed interstitial pneumonia. Both leukocyte migration inhibition test and sensitized hemagglutination test were positive for serrapeptase.

The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial.
Singapore Med J. 1989.
We evaluated an anti-inflammatory enzyme drug Danzen ( Takeda Chemical Industries ) on 70 patients complaining of breast engorgement. Serrapeptase was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85% of the patients receiving serrapeptase had “Moderate to Marked” improvement, only 60% of the patients receiving placebo had a similar degree of improvement.

A case of serratiopeptidase-induced subepidermal bullous dermatosis.
Br J Dermatol. 1999.

Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase — a prospective study
Fortschr Med. 1989.
Using a quantitative standardized procedure, the swelling of the ankle produced by supination trauma was measured. In the 66 patients with fresh rupture of the lateral ligament treated surgically at our Department between December 1986 and April 1987, a prospective study of the effect of serrapeptase (Aniflazym) on post-operative swelling and pain was carried out in 3 randomized groups of patients. In the group receiving serrapeptase, the swelling had decreased by 50% on the third post-operative day, while in the other two control groups (elevation of the leg, bed rest, with and without the application of ice) no reduction in swelling had occurred at that time. Decreasing pain correlated for the most part with the reduction in swelling. Thus, the patients receiving the test substance more rapidly became pain-free than did the control groups. On the basis of these results, serrapeptase would appear to be an effective preparation for the post-operative reduction of swelling, in comparison with the classical conservative measures, for example, the application of ice.

The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus.
Arch Otorhinolaryngology. 1988.
We have evaluated the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. It was administered in a dose of 30 mg/day orally for 4 weeks. Nasal mucus was collected from the nasal cavities of each patient before and 4 weeks after the start of the medication. Serrapeptase reduced the viscosity but not the elasticity of the nasal mucus.

Testimonial by email
I have started taking this enzyme after having it recommended by a chiropractor friend. I have had type 1 diabetes for over 22 years, have macular edema and also a heart rhythm abnormality for which I have been treated with a synchronising pace-maker. I thought you might be interested I my experience. I initially started using 80,000 unit tablets one a day. I upped this to 3 times a day and found this too much as it made me feel weak and breathless. I have now reduced this back to one a day but I think I may get weaker tabs and split the dose. Anyway, what I thought might be of interest is that within a few days of starting the treatment, I am finding my sight improving. Mostly this relates to improvement in colour perception but my floaters also seem less pronounced and some of the fading is reducing. I still have macular distortion but hopefully this might improve too with time.

Emails and questions
Q. Can serrapeptase cause adverse reactions when taking meds for high blood pressure such as Norvasc and Avapro? Because my mom takes those and they really afflict her badly. And what is the ideal serrapeptase dosage for me to take for chronic sinusitis. I’ve had that all my life. I need relief and not drugs.
A. Serrapeptase has been used in Japan but very little in the US so we really don’t know much about the ideal dosage or what conditions it is likely to benefit, or how it interacts with medicines.

Q. My father has found benefit using serrapeptase for his leg claudication. He can now walk twice as far, but still not much, about 400m, but he is 81! I wonder if serrapeptase breaking down plaque. Does it reduce blood pressure?
A. I am still not sure how much of an influence it has on blood pressure.

Q. I began taking Serrapeptase, 30,000 IU from a company other than Physician Formulas, one a day, approximately 2.5 months ago. I am taking no prescription drugs, but am taking various vitamin and herbal supplements. There were no apparent side effects but nor did I notice any noticeable change in my general wellbeing. My brief history: I have been diagnosed with GERD which had its onset 3 years ago after a 2-day bout with food poisoning. Because I did not want to remain on Nexium 40 mg/day for the rest of my life, I changed my diet and began researching vitamin and herbal supplements to replace the foods I could no longer tolerate. The only other conditions I had/have were:
Very mild elevated B/P – corrected
Very mild hypothyroid – supplemented with Thyroforce
Very mild elevated cholesteol – treated with increase in exercise and barely any fat in diet.
Mild osteoarthritis which, like the GERD, flares up and wanes with changes in the weather. Flares not only result in more GERD symptoms but, when severe, feel like flu – achy all over.
I added the serrapeptase supplement because local promotions said it would improve digestion, clean plaque out of arteries, etc. Although I did not make any association at first, for the past month or so I began to have increasing pain in leg muscles and knee / ankle joints. Muscles became really tight and this progressed to the point where I could hardly walk and stairs were almost impossible. Spider veins worsened in number. I had physiotherapy which did not afford much improvement and the only thing that helped was a hot shower and massage with A535 liniment. I could not figure out what was going on until I sat down and made notes about chronology. What was startling was that symptoms began to improve dramatically during the past three days, which coincided with the fact that I had run out of serrapeptase and had not been able to go to my usual natural nutrition store for a new supply. Working back the chronology, there it was – the problem had commenced shortly after starting the serrapeptase. I have looked at the data available online and there seems to be no reference to similar side effects….so it’s over to you. Is this possible? Obviously, there are other things I could mention, but I don’t want to make this any longer than it is already. If you could throw any light on this situation, it would be much appreciated.
A. Thank you for your email, it is quite interesting. This is the first report we have had regarding a possible link to these kinds of symptoms. It is difficult to say whether they are related or coincidence, but it is certainly should no be discounted. Serrapeptase has not been used in this country for prolonged periods and hence we do not know the short term and longer term serrapeptase side effects as well as we do for other vitamins and herbs. As a rule, we often recommend taking breaks from supplements, and this is one of the reasons we do so. Perhaps the dosage of the serrapeptase was too high for you, the serrapeptase that Physician Formulas sells is 20,000 units. Or perhaps it interacted negatively with the other herbs or supplements you are taking, or perhaps this particular serrapeptase product was contaminated with a toxin. You may wish to contact the manufacturer directly. Please keep us updated.

Follow Up Serrapeptase side effect ?
Q. it has been many weeks since we discussed my experience with side effects possibly due to my use of serrapeptase, discontinued at the time I first wrote to you. Eight days ago, I restarted the product taking a single, 30,000 IU capsule of serrapeptase. This time, because I am prone to very early waking, I used that to good effect by taking the capsule on waking and then nothing else for at least an hour. I did that following receipt of the results of my annual check-up – all clear as a bell – BP, ECG, Thyroid, cholesterol, BUN, glucose all within normal limits, although BP is higher at age 71 than it was when I was in my fifties. The three ‘conditions’ that remain symptomatic are the intermittent episodes of right-sided cramping pain which present like gallstones – not confirmed on ultrasound and blood tests. The other two are GERD – which I now keep under control with diet, Tums and the occasional Pariet – and osteoarthritis, which is painful or not largely in response to the weather and which is deforming some finger-joints and causing pain and ‘catching’ in the left knee. For the first few days, I had no adverse side-effects at all. Then, with gradually-increasing intensity, I began to experience increased swelling and discomfort in most joints – hands, knees and feet. Walking became extremely uncomfortable, just as it did previously. In short, the condition I most hoped to improve appears to be worsened by taking the product. I have not taken serrapeptase this morning and, unfortunately, it looks as though I’m out of luck in the future. That’s really too bad, as it sounded so promising.

Q. I tried serrapeptase swallowed as a pill and did not notice much effect on me. Then I tried it under the tongue, and so far I have very good results. I have noticed a sharp decline in my post-op inflammation. It is impossible to tell if this is a direct result of the neutraceutical or the result of being almost six weeks recovered from back surgery. Please note that using this product of yours under the tongue is like chewing sandpaper. If it proves to be beneficial you may want to reformulate it in such a way to be gentler to tender tissue.
A. This is interesting. We have no idea if it works better under the tongue or how safe it is to take it this way.

Q. I saw on your web site that there is at least one other person who has had a negative experience with this enzyme. I too was disappointed and shocked as it caused me extreme muscle and joint pain after two weeks. And it sounded like a product that could have really helped me. I took 2 caps serrapeptase (40,000 units each) on an empty stomach one hour before breakfast. I did this for about three weeks. After I stopped the serrapeptase I did notice some improvement, but it has been a week since then, and I’m still in a lot of pain, joints and muscles.
A. We find this strange since this potential serrapeptase side effect has not been mentioned in the medical literature, yet you are the second person who has reported it to us in the past 3 years. We will keep monitoring this potential serrapeptase side effect. Perhaps the dosage was too high.

Q. I was reading your website in search of anyone with side effects from taking serrapeptase. I just turned 50 and was recently diagnosed with osteoarthritis in my lumbar spine. Otherwise I am perfectly healthy. After taking 60,000IU twice daily for a week, I noticed some intermittent swelling in my hands and a “fullness” in my head. I decided to get my blood pressure checked and it was about 150/90 when it has always been about 115/70. This continued for another few days when my doctor suggested stopping the serrapeptase for 2 weeks. I did this and the swelling left after a couple of days and my blood pressure returned to normal. Three days ago I resumed the serrapeptase at 1/2 the dosage (60,000IU/day) and the swelling and elevated blood pressure (146/92) have returned. Unfortunately, my back improved significantly both times I was on the serrapeptase. Is it possible that the swelling and blood pressure are a side effect of some positive effect the serrapeptase is having and would go away eventually?
A. This is the first we have heard of serrapeptase influencing blood pressure, but it may be possible since the full side effect profile of serrapeptase is not yet known. However, it does appear that the side effects could be dosage related, so we suggest using only 20,000 units a day and taking 2 or 3 days off each week, or using the serrapeptase every other day.

Q. I thought I’d let you know my experiences with serrapeptase (Serralone 400mg per capsule). I started using it in the hope that it would help reduce the appearance of my varicose veins (I am only 32). As it is also an anti-inflammatory I thought it may also help with my adult acne as my infections are prone to being very swollen and red. Well, it seems to have certainly helped with the acne swelling, my spots are not as inflamed and angry looking but I have developed an awful lot of spider/thread veins that I never had before and I didn’t notice and difference to my varicose veins. I have stopped taking it now as I am worried about the thread vein situation worsening.

Q. I have looked through the previous newsletter articles but can find nothing on serrepeptase. Are you able to advise serrapeptase dosage and length of time that you consider safe to take the supplement (I have been taking it for chronic sinus infection as well as osteoarthritis and ankylosing spondilytis) and what sort of breaks you consider best.
A. The reason we do not have specific dosages and length of use is because there are hardly any human studies that can give us these answers. Hence, until we know more, we feel it is best to take frequent breaks and discuss with your doctor on further details. Your doctor may wish to read this page on serrapeptase.

Q. I refer to a category of systemic enzymes which are fibrolytic —  fibrolytic enzymes break down fibrin and reduce or prevent scarring. Examples of these are serrapeptase and nattokinase. So, more precisely, could a fibrolytic enzyme like serrapeptase possibly reduce the fibrosis in an inflammation damaged esophagus (as in eosinophilic esophagitis) or an inflammation-damaged airway, as seen in asthma? Both undergo eosinophilic inflammation and with time, remodeling which includes fibrosis.
A. We really do not know, there is so little research done with serrapeptase, hopefully we will know more in the next few years.

Q. Are there any studies saying whether or not serrapeptase would be helpful in costochondritis? Also, why would spider veins be a symptom of serrapeptase use?
A. I am not sure why spider veins are related to the use of serrapeptase. I have not seen research regarding serrapeptase and costochondritis.

Q. I have read a lot about serrapeptase from your website and I am wondering how it will help with scar tissues formed after myomectomy surgery of six years ago.  I read in your website that only little research has been done on serrapeptase and edema which I interpret to mean scar tissues; is this correct.
A. Edema is fluid accumulation in tissues, it is not a scar. We don’t have any research on serrapeptase and post myomectomy scar formation.

Hello, and greetings from Paris. I just came across your great website and was particularly interested by the reports about serrapeptase side-effects. I am considering to start taking Neprinol or Vitalzym for my fibroid problem. While reading the ingredient list of both supplements I noticed that they don’t give the exact amount of serrapeptase included in their formula. All they say is that one tablet contains 500mg or 15000 units of their mix of enzymes. How is one to know the amount of serrapeptase included in that blend? I am worried that if I adhere to their recommended dosage my intake of serrapeptase might be too high. On the other hand, I am really interested in reducing the size of my fibroid. Do you think it would be an option to take your recommended dose of 20000 units/day of serrapeptase alone without the other enzymes? I can get serrapeptase here in France without a prescription.
It is best to ask the manufacturers of Neprinol or Vitalzym regarding the dosage of the serrapeptase in their products. As to serrapeptase and fibroids, we have not seen such research yet, and you may consider reading about fibroids on this website.

How is serrapeptase manufactured? Do they kill silkworms to do it? I have several friends who are interested in a product but they are all vegetarians.
It is made by specific bacteria found in the gut of silkworms and these bacteria “digest” their cocoons. That is the extent of our knowledge, the exact steps are not revealed to us by the manufacturer.

I have visited a few websites, and came across yours. You seem to cast some doubt on the use of this supplement, in regards to the amount a person should take. I went to another site and found out that it has been used for at least 25 years, with NO side effects. It has been used in Europe, and Asia, doctors prescribing and using it to treat patients with major problems. I would tend to use this supplement, then use some prescription drugs, with major side effects, as we have seen in the past few years, especially with arthritis drugs.
There is a lot of information published on serrapeptase and other supplements on the internet. It is up to the consumer to decide which web site they find the most reliable and honest. We still have a lot to learn about its full benefits and risks.

I’m adding to your data re joint/muscle pain side effects – I ordered the enzyme from Nutri-Health – object was relief of sciatic pain from traumatic injury of several years ago, on the theory that the nerve might be irritated by scar tissue. Total relief after 48 hours (4 doses of 20,000), but I continued it for a few more days to see if it would help with knee pain from torn meniscus. Overall achiness and finally real pain kept increasing to the point that I was finding it difficult to move when I found your site with the few references that matched my experience. I recovered from that effect after 2 days and stayed off the enzyme for a couple of weeks. Last week I tried it again to be certain and within 2 days began the pain once again. This time I have stopped the serrapeptase for good. There is probably no interaction involved as I take no prescription drugs, but do take many antioxidants and other supplements that reduce inflammation. However, I do test positive for rheumatoid arthritis although I am symptom-free through a strict diet.

Does it desolve kidney cysts?
I have not seen any studies regarding the role of serrapeptase in kidney cysts.

Is it okay to take a Wobenzym supplement together with a serrapeptase enzyme product?
Not much is known about the effects or results of combining serrapeptase enzyme with Wobenzym supplement, therefore I suggest not taking them the same day.

Will serrapeptase dissolve scar tissue, as some claim? Also, I ordered some serrapeptase tablets that are 80,000 units. They made my blood pressure go up.
As of 2013, I am not aware of any human studies regarding the dissolving of scar tissue with the use of serrapeptase supplements. The use of serrapeptase pills and research regarding this product is quite new and I suggest using lower dosages until more information is available.

Greetings from Cambridge, England. It may be useful if I responsibly recount my serendipitous experience. Around two years back a colleague suggested I try a few low-power daily capsules to see whether sharp big-toe joint pain might be alleviated. Gout it resembled but gout it was NOT, as my general practitioner doctor discovered to his puzzlement when the standard uric acid lab test came back negative–nonetheless, stomach-irritating anti-inflams were offered with commiserations. I opted to try serrapeptase pills instead and found that the inflammation subsided quickly and with no stomach discomfort. An unexpected side-effect, however, was that dead-tissue collagen growths in my hands (bi-lateral Dupuytren’s contractures) began to itch and tingle, and over the next couple of weeks finger dexterity loosened up noticeably. Background info: Two senior UK hand-surgeons, one of them US qualified, had advised against excision and z-plasty in my case as growths were judged aggressive and advanced, likely to recur within five years of surgery. I was encouraged to await availability of Santyl collagenase injection therapy (undergoing phase 3 trials and FDA control at Stoneybrook, Detroit, and elsewhere). ‘Delay surgery as long as possible! Try and wait’, said the surgeons. (And Phase 3 is not yet done.) Bent ring fingers have straightened up considerably as a result of my taking enteric coated serrapeptase, 30,000 iu each day over the last two years. The growths are visibly and palpably retreating, and I can now press my palms flat on a table top. Maybe the cords will wither away or snap and dissolve as I nowadays flex fingers to degrees which were impossible before. Presumably my lymph system is perforce processing a lot of dissolved dead tissue, unhealthy material, and this may well be a debilitating strain on the body’s daily attempts to achieve homeostasis. I imagine that rises in temperature and occasional flu-like symptoms might be triggered when my body needs to rid itself of unwanted solutions. General practitioners seem puzzled and skeptical. They say nothing. A very senior hospital specialist treating chronic pain knows the enzyme and its use in state regulated medicine in Germany and Japan (for fibroids, blocked arteries, etc.), and has no reservations whatever about my using serrapeptase. I realise that this does not add up to longterm controlled trials and verifiable findings. Obviously I am pleased to get my hands back into better shape and fitness for purpose, but perhaps I am at risk as we do not know if longterm damage elsewhere in the body can result from bioactive agents taken extensively. I see a parallel with the Santyl collagenase enzymatic injection trials, taking the original enzyme from the King crab, I hear, not the silkworm as in serrapeptase, but the Santyl approach is a targeted, more topical and contained treatment.

Last month I had a severe inflamation in my mouth to my throat, partly because of my allergy. I was already feverish and coughing so hard. I remembered from my research about serrapeptase that it is also good for inflamation, so I placed 3 tablets in my mouth in the morning (I did not swallow). In my surprised, in the afternoon the inflamation subside. I took another 3 tablets in the afternoon, and another before i sleep. The next day, in the morning, the inflamation in my mouth were totally gone. Since I could still feel a little on the lower part of my throat, I continue to take 2 tablets 2x a day with an empty stomach. Until now, I did not feel any side effects. In fact, I did not anymore feel the pain in my stomach due to symtom of myoma.

This brand works SOOOOO much better than others! Bought this for my husband and within a couple of weeks his joint pain was significantly diminishing. After an entire bottle he had very little joint pain. Nothing else works to relieve his pain like this brand of serrapetase. Tried another major brand and it didn’t work at all so now we’re back to Drs Best. Going to stick with what works. Prescription meds don’t work as well as this and have many more negative side affects.


I could not believe how fast my broken tail bone healed after I started taking this. Anyone who as ever suffered through this know it takes months and years to heal. I took quite a bit more than recommended, (9)/day, but in two weeks time I am sitting and not in pain!!! This is my second time for breaking my tail bone so I can compare it directly to before. I am still amazed that it doesn’t hurt. I quit taking it and the pain hasn’t come back. This is amazing. Far exceeded my expectation.

I have taken other serrapeptase products, without such excellent results. I have seen amazing improvements to my skin in these last couple of weeks – it is smoother, younger making scars less visible. It also fights inflammation. I feel absolutely great. I also gave it to my mom who is in her eighties. She is seeing improvements such as mobility she has not seen in a couple of years. (REFERS TO dOCTORS bEST BRAND).

After two weeks of taking Serrapeptase, there were positive external changes with no side affects. Taking 10 per day and will eventually scale down to a maintenance dosage.

my sister and i both take it for arthritic hands and she takes it for high cholesterol too. both of us have seen huge improvements in motility and pain in our fingers. she dropped her cholesterol 10 pts. in 6 weeks only using 4 per day. my mom takes it also. arthritis everywhere. she has been able to sleep better with less pain on 4 per day. i am so thankful for this product

What has happened was that the bursitis in my hip cleared up in a couple of days. I had it for months and it hurt at night time and now it has gone. Amazing.

Can be good for removing eye floaters.

Very effective in removing dead proteins from the body.

Has been very effective in removing the crud in my lungs from smoking and keeping those vital tubes leading to me heart from blocking. I think every smoker needs to be taking this stuff. I describe it as my internal garbage collection molecule, that attracted to the rubbish in my system, collects it and dumps it out appropriately. First discovered it helping a girlfriend with Varicose veins.

Serrapeptase has been a miracle in my life. Once I turned forty my health began to fall off dramatically. For nine years I was progressively more ill – arthritis, heart attack, emergency back surgery, diabetes, all kinds of trouble! I began taking Serrapeptase a year ago and I am (with my doctor’s approval) off of all my medicines and totally pain-free! Most days I feel like I am back in my 20’s!

I tried Serratiopeptidase enzyme From Doctor’s “Best Proteolytic enzymes” and felt sore throat and some breathing problem, felt like being choked. Used it for about 10 days. I started to have inflammation of the lungs and the sinuses.

Started taking one capsule in the morning an hour before I ate breakfast….got extreme dizziness and nausea…both symptoms got better as time went on and did feel much less pain, more energy, but stopped taking the pills because tired of dizziness and nausea feeling…will try to take again later because it really did relieve pain so well…am hoping the dizziness and nausea were from something else, maybe a bug going around.

I used this with the intention of “dissolving” an internal scar. I had no big faith in it but I tried it anyhow. The first day I took 3 times 2 pills. And I had some realy weird side effects (especially during the first night!) like ‘mental agitation’, ‘restlessness’, ‘thinking in overdrive’, ‘sweating’, ‘fear’. also it seemed I was constantly short in breath and that I had to make effort in order to breath. It was like I took some speed with poison or something. after the first day, the side effects strongly diminished, but I also diminished the dose to 2 to 4 a day. I gave still two stars, because I quited after one week. I am planning to give it another try, and take it some longer time.

October 21, 2013.
I was using three caps, three times a day but I noticed an huge increase in joint pain. I think this was my bodies way of telling me to back off. I’m back to one capsule three times a day. Almost immediately the pain went away.
I’ll stay at this dose for the rest of the time I use serrapeptase. I’ve read that full results can be expected in the eight month to one year range. I’ve been using for three months. Even at an increased dosage there was no further impact on my eye floater or anything else really. I think I’ll use for eight months and then do a final update then. Today I started using Dr. Christopher’s Eyebright wash to see if that gets rid of the floater.
We’ll see…

November 4th, 2013.
I have stopped taking serrapeptase for the time being. I have suddenly developed shooting pain in my right hand, left knee and various other body parts. It went away two days after stopping serrapeptase. Maybe I was taking too much? Maybe I no longer need it? Maybe I just needed a break from it? I’ll resume and finish the bottle in a few weeks. If the pains returns my body must be telling me I no longer need to take this.

November 11th, 2013.
I have resumed taking serrapeptase at the recommended dosage of one capsule three times a day. I may also do a few weeks to a month of taking it and then take a few weeks to a month off. I’ll see how I feel about it later.

Review update 01/15/2014
I thought I was done with serrapeptase….WRONG!!! The last dose I took was on 12/30/2013. A little ache and pain that I thought was gone for good has come roaring back with a vengeance. Sciatica in my left leg is absolutely agonizing even with stretching. Welcome back serrapeptase, good bye leg pain. Don’t know what you got till it’s gone……….. Same with pain……..I sort of forget just how bad it is till it comes back. It does work for pain after all.

Review update….07/16/2014
Plantar Fasciitis cure found. About three weeks ago I was walking home from work and a piercing pain developed in the heel of my left foot. I thought I had a rock in my shoe. I sat down, took my shoe off and there was nothing there. OH OHHHH!!!
I knew right off the bat what that meant…the return of the dreaded plantar fasciitis. Funny thing is…I didn’t hurt my foot, I didn’t bang it, didn’t hurt it exercising. The little bout came out of nowhere and it stuck around. I tried increasing my vitamin d3, k2, taking curry, and for three weeks I stumbled around. Hurt to stand. Impossible to walk. Then yesterday……..DUH…….serrapeptase. I took three caps three times a day. One day, ONE DAY later…zero pain. Miracle!!!

I see your interesting comments, you should ALSO be taking Nattokinase. Some products combine both. There is Doctor’s Best NattoSerra, there is a product called Serranatto. I know a person who stopped Tregeminia Neuralgia pain with Serranatto.
Reason behind this combo: Serrapaptase dissolves dead and inflamed tissues from the body – you need to address the elimination process, make sure it gets out of your system. Hence Nattokinase that improves circulation .

I have had Restless Legs for about 10 years. I didn’t really notice it at first, but about 3 weeks after beginning this supplement, I realized that the RLS has decreased by about 80%. I’m astonished! I’ve tried EVERYTHING for RLS and achy joints after being on my feet. I don’t get it, but so far I’ve been taking it for about a month and I am really thrilled with the results.


My plastic surgeon prescribed it for my surgical wounds and trauma, and instructed me to take one pill (40,000 units) every six hours away from food (1 hour before or 2 after). My Dr. said I could cut the dose in half after 6 weeks if I wanted, or could continue with the initial dose for six months or even longer. My Dr. advised me to rest for a week or two at 3 months and continue until I finished treatment. It speeds up healing. It reduces scar tissue.


Ihave a 2 yr old rescued pit bull with hip dysplasia. It was getting to the point where anytime she played or walked more than a block she was in pain & limping. We took her to an orthopedist who recommended a hip replacement, but he didn’t want to do surgery before she turned 3 because she wasn’t fully developed. She was on Glucosamine/Chondroitin with very little improvement. I came upon this supplement for chronic sinus inflammation which I was suffering, but also read the reviews on how it helped arthritic dogs, so I thought I would try it out for her. Within days, she was running, jumping & playing with no pain or limping. Honestly, it was miraculous. After a few months we had a follow up with the orthopedist who was amazed at the difference. He doesn’t want to move forward with surgery at the present time since she is doing so well. We then started my 12 yr old Rhodesian Ridgeback on it & he’s acting like a puppy again.


This is no cure for my fibromyalgia and chronic fatigue, but IT IS THE ONLY THING THAT HELPS ME! You have no idea the thousands and thousands of dollars I have spent over the last 7 years trying to get well. Doctors were no help at all. I have tried just about every herb and product on the market seeing absolutely no results at all. Finally, I discovered Serrapeptase and I have gotten part of my life back again. Using serrapeptase I feel better, have more energy, and can actually exercise a little bit now. I am also noticeably happier when taking serrapeptase. I initially tried this together with nattokynase and feel the serrapeptase is what really helps me. Nattokynase does not help me as much. I actually feel better just taking the serrapeptase. Absolutely no negative side effects at all with this product.

it does all kinds of good to destroy biofilm (colonies of bacteria). See ‘How Stuff Works’. This is recommended for people with Lymes, Candida, etc.

CFS is the result of low hormone levels. Use Smoky Mountains Natural Estriol Cream 150mg & Progesterone Cream 1,000mg 2x a day 1/4 teas plus 25 mg of their DHEA and you can regain your life! I am living proof it works. I’m 61 and feel 20 years younger now.

This product is a very important part of my natural blood thinning and cardio vascular daily supplement regime after a DVT in one of my legs and resulting pulmonary embolism incident over a year and a half ago. For the first 8 months or so I was on Warfarin, but didn’t like the associated risks (after all it is Rat Poison) and costs, both monetarily and in life style, i.e. having to go in for frequent INR checkups. So after a lot of research I decided to go with a daily Nattokinase and Serrapeptase combined natural treatment, which I’ve now been on for almost a year. As a follow up I recently had ultrasounds done to check over a concern over a possible new DVT in the lower extremities given my history. Result? Much to my relief… clean as a whistle with absolutely no sign of any problems. As a further benefit compared to Coumadin/Warfarin, I do not have any of the bleeding issues I had when my INR readings were high.

I found out that I have an 8CM Ovarian Cyst, I was in very bad pain, to the point I couldn’t do anything except lay down. My Gyno sent me for MRI and I was already thinking of scheduling a surgery. The pain was unberiable. My doctor told me it may start shrinking after a couple of cycles and may not, she wanted to wait and see. After my MRI and seeing how bad it really was, I did a lot of research myself and came across Serrepepraase. Let me tell you, in 2 days my pain was completely gone. It made me feel like it was working as a pain killer. In 10 days of taking the pills I signed up for a second opinion to a surgeon and while I was waiting for him, I asked to do my Sonogram again. Guess what – my cyst was gone!

This is the best thing I’ve ever done for my health. It lowered my BP the very same day by 10 points. I’ve been taking this religiously for 5 months and get this: I NO LONGER HAVE BLOOD PRESSURE. I rarely go above 130 these days and that is when I forget to take the supplement for several days.

Ever wonder how Japanese stay so thin? They take these enzymes. This stuff is amazing. Lost 5 pounds on it.

It has been demonstrated that in 12-18 months, arterial plaque can be eliminated from human arteries and that it is much more effective and less invasive than EDTA chelation therapes, and pennies on the dollar, as well.
Besides, my belly fat has gone down, but I’m not sure it’s the Serrapeptase, as much as the DIM I take.I take this Serrapeptase along with the Nattokinase every morning religiously, 2 capsules each. I take them together because they’re supposed to work synergistically and many people also do so. I also take 2 capsules of DIM along with them, and 2 Vitex later in the day.

This works very well but fibrinolytic action can make minor blood vessel damage much worse by causing excessive internal bleeding.

Severe asthma, semi-invalid, couldn’t climb stairs, out of breath after walking a few steps. It opened my lungs & I can climb stairs & walk around in a mall & exercise. Still have asthma, but so much easier to live with. A large visible painful lump of scar tissue on my thumb from surgery disappeared, can’t be seen & no longer painful. Took about 6 months. CAUTION: When lungs open, the tissue will be tender & not used to pollution. Take it slowly & try to avoid chemicals, paints, smoke, etc. I felt better and was using paints, glues, polyurethane, etc & got pretty sick. Ater that, I bought an electric salt air solanizer to keep in my room at night & help heal the lungs. I’ve read that it helps clear clogged arteries. Almost forgot, cracked my ankle/had pain for 30 years, pain is gone & painful breast cysts I had are no longer painful & I can’t feel them. Now, I take it after a cold or flu for inflamation & to prevent further lung damage. These enzymes eat dead tissue & I’ve had no side effects from it.


I have been looking for a alternative to Rx drugs to control my high blood pressure. I stumbled across Nattokinase and it was suggested to add Serrapeptase, so I did. The combination seemed to be working within the first two weeks of use……buuuutttt, both my wife and I started getting extremely dry and stuffy sinuses. To the point of waking up in the night not being able to breath and being very painful. After a bit more research I found that the serrapeptase is useful for sinusitis, we stopped taking it and within three days our sinuses are about back to normal. So be aware.

Jun 11, 2014 unfortunatly this product contains Enteric capsules which are toxic to the body because it changes the testosterone into estrogen and vise versa. please look up “What Are Phthalates & What Are They In?”  (Editor;s note, the enteric coating may have now been change by the manufacturer to a calcium forumulation, not the more harmful enteric which contains plastic and is often used on health supplmenets).

. I originally started taking it because I had a previous blood clot, was planning to travel and worried about another, it also helped with my sciatica. after taking it for a couple months I quit for 3 weeks to see how I would feel and realized I don’t want to live without it.

I have been taking serrapeptase for back pain due to ruptured discs, and have had little or no significant pain after taking for 2 weeks. I gave my Mother who is 81 years old the serrapeptase because she was having problems with ankle swelling. Well after 30 days on the serrapeptase her swelling is completely gone

I feel like no more crunchy neck and no more back sore in the morning.

This enzyme eats dead tissue. It is able to free blocked or clogged arteries by digesting the plaque coating the inner walls. Good Anti-inflammatory

I had been struggling with sinus for about three months. The products that normally worked for me were not having their desired effect and I was becoming weary from the insidious nature of sinus. I stumbled across this product and thought I might as well give it a try. After only taking one tablet my mind felt clearer than in 3 months and after a few days of taking three tablets a day my sinuses were fully cleared.

My husband had chest pains every day for a few months and he's not yet 30. I was very worried about heart problems but we had it checked out and found that it was actually a condition called costochondritis, which is the inflammation of the rib cartilage. I gave him 2 caps a day to start with, but didn't have much of an effect. Then I doubled the dose to 4 caps , sometimes twice a day when I remember, or only at night before bedtime.He hasn't had a chest pain for 2-3 weeks straight and I firmly believe it's the serrapeptase.


After months of pain, tingling, burning sensation, and numbness in my right foot I was diagnosed with Morton’s Neuroma. The recommended treatment was a round of cortizone shots…extremely painful to endure and seemed to only exasberate symptoms. Began researching online and found much written about using Serrapeptase to treat this condition. After a few days, lots of improvement. I am now on week three and will continue for a total of 6 weeks as suggested by some experts.

I started out taking 3 pills a day and had a slight improvement in my breathing and I switched to 6 pills a day and do not have to take an inhaler to breath for the past 2 days and it has been 3 weeks not even a complete month yet.


I have a severe lung condition for which there are no prescription medications. I have been seeing an herbalist for a year and a half and during that time I have been stable. Serrapeptase is one of the supplements I take every day.
I’ve been using the enzyme for only two months now and I’m on my second bottle. Here are my results so far…

The floater in my left eye has gone from looking like a pitch black gnat in my field of vision to a very pale, opaque dot that I barely notice anymore. I would judge serrrapeptase to be a colossal victory in that area. I am hoping it fades altogether to the point where I no longer notice but that may take much longer.


September 26, 2013…..review update.
I am at a standstill with my eye floater and scar tissue in my back. Nothing has changed so after a ton of research I am going use a higher dose. I was taking three capsules a day. I have increased it to three capsules a day, three times a day. I will stay at that dose for two weeks, each week I’ll drop it down by one cap per serving till I’m back to three capsules a day. If this manages to knock out the eye floater and the remaining scar tissue I’ll keep taking a maintenance dose of serrapeptase for as long as I feel is necessary.

Tell Somebody!