DMAE for healthy brain function; supports neurotransmitter production; improves mood, enhances memory, and improves brain function. Anti-aging effects on skin, can help in diminishing issues with skin sagging and promotes greater muscle tone. Also an anti-oxidant. Found in minute quantities in the brain, it is a precursor to the essential nutrient choline, which the brain requires to produce acetylcholine, a neurotransmitter crucial for nerve signal transmission and healthy brain function. Improves immunity, may increase energy and reduce fatigue.

May help with brain fog.
Could cause headaches due to the increase in choline.

In reviews, people have said it definitely enhances alertness and concentration and “allows me to think more clearly”

“In combination with other supplements such as L-carnitine, fish oil, etc. it has helped to delay the aging of my skin. At 70+, I have good texture, color, and thickness”.

“Also seem to lighten my dark pigments/sun spots – and I checked with scientific literature : it actually might seem to remove plaque that stems from (over) pigmentation! That is really awesome, and something I have been trying to get rid of for ever, with creams, staying out of the sun, extreme sun filters and, and, and….”

“Great for clarity, recall, energy, skin improvement, and even weight management. The negatives are that it causes me insomnia, headaches, irritability, and sometimes depression. I have been experimenting stacking this with L-Tyrosine and that appears to improve the negative side effects.”

I saw visible lightening of the “age spots” on my hands after about a month of using this product, and that was only taking once a day. I will be upping my doses to 2-3 times a day. Takes some discipline since they should be taken on an empty stomach, but worth the result!(Now, 250 mg capsules)

May prevent or improve:

DMAE may also help prevent the buildup of beta-amyloid in the brain. Too much beta-amyloid has been linked to age-related decline and memory loss. DMAE’s impact on Ach production and beta-amyloid buildup may make it beneficial for brain health, especially as we age.

benefits of dmae

  • Reduce wrinkles and firm sagging skin. A randomized, clinical study reported in the American Journal of Clinical Dermatology found that a facial gel containing 3 percent DMAE was beneficial for reducing fine lines around the eyes and on the forehead when used for 16 weeks. The study also found it improved lip shape and fullness as well as the overall appearance of aging skin. A small studyTrusted Source done on humans and mice suggested DMAE may hydrate skin and improve skin appearance.
  • Support memory. A small amount of anecdotal evidence indicates that DMAE may reduce memory loss associated with Alzheimer’s disease and dementia, but there are no studies to support this claim.
  • Enhance athletic performance. Anecdotal evidence claims DMAE may help improve athletic ability when coupled with other vitamins and supplements. Research is needed to support this, though.
  • Reduce hyperactivity. Studies on children done during the 1950s, ’60s, and ’70s found evidence that DMAE helped reduce hyperactivity, calmed children, and helped them focus in school. No recent studies have been done to support or deny these findings.
  • Support better mood. Some people believe DMAE may help enhance mood and improve depression. A small study done in 1977Trusted Source on people who had aging-related cognitive decline found that DMAE reduced depression, anxiety, and irritability. It also found that DMAE was helpful for increasing motivation and initiative.

in high doses, inhaled, or used topically, DMAE has been associated with several potential risks, according to the National Institutes of Health (NIH). These include:

  • skin irritation, such as redness and swelling
  • muscle twitching
  • insomnia
  • sneezing, coughing, and wheezing
  • severe eye irritation
  • convulsion (but this is a slight risk for people susceptible to it)

Drug Interactions

Anticholinergics are used for a wide range of conditions, including Parkinson’s disease, COPD, and overactive bladder. They work by blocking the effect of Ach on nerve cells.

Since DMAE may increase effects of Ach, people who need these drugs shouldn’t take DMAE.

Cholinergic medications

Cholinergic drugs may block, increase, or mimic the effects of Ach. They’re used to treat several conditions, including Alzheimer’s disease and glaucoma. DMAE may prevent these medications from working effectively.


You shouldn’t take DMAE if you use certain blood-thinning medications, such as Warfarin.

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