In researching why simply IV saline solution made my mom recover so well when she was having seizures, involuntary jerking movements, and crazy dry skin – and why it really popped her back to life – I came across information stating that it can really revive some patients (including debilitated chronic fatigue patients) if they have low blood volume, because the iv fluids increase blood volume. So this is a track I want to investigate further. I think it is possible my mom may have an issue with low blood volume. Below is the research I am gathering.

Note the reference towards the end about treating with licorice.




Treating Low Blood Volume and Decreased Heart Function in CFS

In this important article we will discuss a critical but usually overlooked part of treating CFS and fibromyalgia effectively. It can be relatively easy to treat, but is not very glamorous, and is therefore often forgotten. We will focus on new research by Dr. Barry Hurwitz and a team of University of Miami researchers, including Dr. Nancy Klimas, who is wonderful and one of my favorite people in the CFS community (though I sometimes disagree with

her, I’ve always had enormous appreciation and respect for her).


Their recent study shows that patients with CFS have:


  1. A lower blood volume (basically are dehydrated),


  1. Fewer red blood cells to carry oxygen and nutrients (basically anemia, despite normal blood tests).


The study also discusses that although the heart may be smaller in CFS and beats less efficiently, this is likely caused by the dehydration and low blood volume, as opposed to primarily being a heart problem.


The good news is that all of these issues can be effectively treated and optimized naturally — which can leave you feeling much better!


The Bottom Line First


There are several key things that you can do to treat the low blood volume and low blood cell levels that will leave you feeling better.


Treat the dehydration. Despite your increased thirst and drinking a lot, most of you are still dehydrated because you’re urinating even more. This occurs for several reasons, including underactive adrenal function and a decrease in antidiuretic hormone (“anti-peeing hormone”Wink, both of which are routinely present in CFS because of the hypothalamic dysfunction (“blowing a fuse”Wink that we often discuss.

This is why you find yourself “drinking like a fish and peeing like a racehorse.” Quick fixes:


A – Drink more water! Instead of counting glasses of water (an annoying way to spend the rest of your life), check your mouth and lips to see if they are dry. If they are, drink!


B – Eat more salt. Unless you have high blood pressure or heart failure, you need more salt than most people. In fact, many studies have shown that the more salt people eat the longer they live, and for most people the need to avoid salt has been a problematic medical myth (see six dangerous Medical Myths). Use an iodized salt or better yet sea salts (Cosco has a Mediterranean sea salt that is cheap). Enjoy salty foods as well.


C – Improve adrenal function. This is discussed at more length in Adrenal Support, but a simple way to do this is with an excellent product called Adrenal Stress End.


D – Clinical experience has also shown that salt water (saline) IVs can be very helpful. The effects are transient though, unless other nutrients are added (e.g., the Myers’ Cocktails at holistic physician’s offices, or better yet the “Standard IVs” at the Fibromyalgia and Fatigue Centers).


Increase your body’s production of red blood cells. Although treating the infections and hormonal problems we discuss overall in the SHINE Protocol will do this, below are key things that will help.


A – Treat for low iron — even if your blood tests are normal but modestly low. The best blood test is called a “ferritin” level. Your doctor will say it is normal if it is over 12, but research has shown that in people with chronic fatigue, iron supplementation increased energy dramatically in people with a ferritin under 50 (see Iron Helps Fatigue — Even with Normal Iron Levels and No Anemia) who were not anemic. If the ferritin blood test is under 50, or the iron percent saturation blood test is under 25%, take 1-2 tablets of iron (29 mg with vitamin C) each afternoon or evening on an empty stomach for 4-6 months.


B – Treat the low testosterone and low thyroid levels — despite the normal blood tests. Both of these, especially the testosterone (use only the safe and natural bioidentical forms), increase red blood cell production.


Improve your heart function. Though the study discussed in this article notes that the low blood volume and anemia are key, other studies and clinical experience show that nutrients that improve heart function also improve energy in CFS patients. These include:


A – Ribose (Corvalen) 5 gm (1 scoop) 3x day for 3 weeks, then twice a day.


B – Acetyl L-carnitine 500 mg 2x day (see research abstract at CAT.INIST).


C – The Energy Revitalization System vitamin powder (contains 50 nutrients including B vitamins and magnesium).


D – Coenzyme Q10 at 200 mg daily.


Give the above treatments 6-12 weeks to see the effect. But by one month, most of you will be feeling a lot better with these treatments. In addition, if you have not already done so, do the free Symptom Analysis Program to tailor an overall treatment protocol to your case. Although you do not need to have your blood tests results, if they are available the program will also analyze the more important tests.


In addition, I recommend that you see physicians at the Fibromyalgia and Fatigue Centers nationally — they know how to help you recover from your CFS and fibromyalgia.


What the Study Shows


The study looked at 146 people with chronic fatigue syndrome, 30 of which were very severely affected. It compared them to healthy controls and then factored in how active or sedentary the people were. People with CFS showed 25% lower heart contractility, so they pumped much less blood. They then did specialized testing which showed what the person’s total blood volume was and also whether they had enough red blood cells, both of which have been shown to be low in the majority of those with severe CFS.


As all of the above problems have been shown to be common in CFS, the study explored whether there was predominantly a heart problem or whether all of these findings could be explained by dehydration and having too few red blood cells. I would note that, normally, having too few red blood cells would be called being anemic. Unfortunately, the standard blood tests for anemia compare the amount of blood cells relative to the blood volume. As both are low, the blood count tests come back as normal despite CFS patients in reality being functionally very anemic. As the study authors note “the elevated prevalence of low red blood cell volume suggests that the CFS subjects may have an anemia type that goes undetected by standard hematologic evaluations.” In other words, people with CFS are likely to be anemic despite normal testing (being 6-13% lower than optimal depending on the severity of their CFS).


The role of decreased heart function in CFS has been a major focus of work by Dr. Paul Cheney, a chronic fatigue syndrome expert who is intimately familiar with the effects of heart problems, as he needed a heart transplant himself. He theorizes (and I am markedly oversimplifying his theory) that heart function decreases as an adaptation to not being able to properly handle the oxygen needed to make energy in CFS.


Chronic disease in general can trigger dehydration and low red blood cell volume, so there are many possible reasons for these occurring in CFS. Deconditioning can also then decrease heart function. This study was associated with another study looking at whether injections of a prescription blood cell stimulating hormone called “erythropoietin” would be helpful in CFS, which would naturally lead to some focus towards interpreting the results as being associated with a deficiency of blood cells as opposed to a heart problem. The benefits of erythropoietin treatment were modest relative to the cost and hassle though, and I think the researchers’ bias is fairly modest.


The authors conclude “given these findings, it may be prudent in the clinical setting to perform a direct examination of blood volume status in CFS patients and consider treatment for those with abnormal levels. A blood volume deficit may impact adversely oxygen delivery and nutrient supply, impair hemodynamic regulation (e.g., blood pressure and heart function), and contribute to the exacerbation of fatigue and other CFS symptomatology.”


As their earlier study showed minimal benefit from only increasing the amount of red blood cells using erythropoietin, it again shows the need to use an overall treatment approach to treat all the problems present in CFS. These include raising red blood cell mass and treating the dehydration, but also treating the underlying infections, adrenal under activity, and other problems that are at the root of these problems. As we know that most people with CFS will have the dehydration and “anemia despite normal blood testing”, I don’t think it is worth the cost of doing these expensive nuclear scans, but instead recommend the simple treatments discussed in the summary above, which we know are helpful in CFS. These are part of the SHINE Protocol.




1Low Blood Volume and Red Blood Cell Mass study:


Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function. Barry E Hurwitz, Virginia T Coryell, Meela Parker, Pedro Martin, Arthur Laperriere, Nancy G Klimas, George N Sfakianakis, and Martin S Bilsker. Clin Sci (Lond), May 26, 2009; online ahead of print (see abstract).


2Reference for Iron study:


Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial.F Verdon, B Burnand, C-L Fallab Stubi, C Bonard, M Graff, A Michaud, T Bischoff, M de Vevey, J-P Studer, L Herzig, C Chapuis, J Tissot, A Pécoud, B Favrat. BMJ Volume 326 24 May 2003. 1124-8


Source: health_articles_c/ Cfs_fmtreating_low_blood_volum e_and_heart.html treating-low-blood-volume-and- decreased-heart-function-in- cfs-article239-110.html




I’m an Advocate

3 years ago


Group Leader•4 years on site•2573 posts

So, the bottom line is that low blood volume can cause higher blood pressure because the heart is working harder to circulate the blood.


I’ve noticed that a lot of the members here are on Vitamin D, and/or Iron. One of the roles of Vitamin D is to modulation of cell growth, and iron is important for obvious reasons. Both of these affect the blood, I would suggest having your doctor check the levels on both. Then start screening the thyroid, you might have to see an endocrinologist.


JoSh11 JoSh11

3 years ago


VIP Member•5 years on site•2369 posts

At one time I had reduced the salt in my diet because it was supposed to be healthier. i cut the salt called for in recipes in half, & never salted my food at the table.


Then I discovered I had Mitral Valve Prolapse. A very common heart condition, which worsens with inadequate blood volume. The solution? Salt.


Live & learn.


whiteviolets whiteviolets

3 years ago


Member•3 years on site•798 posts

Yes! Laughing


I’ve recently had two doctors tell me to have more salt! So strange!


girlfriend girlfriend

3 years ago


VIP Member•5 years on site•4534 posts

Maybe this is why I crave salt! Very interesting article…. but, is the Adrenal treament safe to take with all of our other meds?


Another question, my blood says I have too much iron in my system… I take b12 without iron added…. does anyone know how this fits into the picture? or even a natural way to reduce the iron? I have searched and found nothing….


JoSh11 JoSh11

3 years ago


VIP Member•5 years on site•2369 posts

First. I looked at the ingredients in Adrenal Stress End:


vit c – fine


B6 – good as a nerve tonic, fine


pantotnenic acid – a.k.a. B5, good for the immune system, fine


Adrenal polypeptide fractions – they don’t really say what this is or what it does. Polypeptides, in general, are chains of amino acids from breakdowns of proteins.


Betaine – a digestive enzyme, naturally occurring in pineapple, fine.


L-Tyrosine – an amino acid, fine


Licorice Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.


The effectiveness ratings for LICORICE are as follows:


Possibly effective for…


Heartburn (dyspepsia), when a combination of licorice and several other herbs is used. These other herbs are peppermint leaf, German chamomile, caraway, lemon balm, clown’s mustard plant, celandine, angelica, and milk thistle. The combination is packaged as a product called Iberogast or STW5. It was developed in 1961 in Germany. Research suggests that taking 1 mL orally three times daily over a period of 4 weeks significantly reduces severity of acid reflux and associated pain, cramping, nausea, and vomiting.


Insufficient evidence to rate effectiveness for…


Muscle cramps. Preliminary clinical research suggests taking a specific combination of licorice and peony (Shakuyaku-kanzo-to) might reduce muscle cramps in people with liver disease (hepatic cirrhosis) or in people undergoing treatment for kidney failure (hemodialysis).


Hepatitis. There is some evidence that some of the chemicals in licorice might be effective in treating hepatitis B and hepatitis C when given intravenously (by IV). But the studies involved too few patients to draw firm conclusions.


Stomach ulcers. There is some evidence that specially prepared licorice will speed the healing of stomach ulcers.


Weight loss. There is conflicting information about the use of licorice for weight loss. Licorice seems to reduce body fat. However, it causes water retention that can offset any change in body weight.


Atopic dermatitis (eczema). There is conflicting evidence about the effectiveness of licorice for treating eczema.












Chronic fatigue syndrome (CFS).


Prostate cancer.


Other conditions.


Licorice is LIKELY SAFE for most people when consumed in amounts found in foods. It is POSSIBLY SAFE when consumed in larger amounts use as medicine, short-term. However, it is POSSIBLY UNSAFE when used in large amounts for more than four weeks. Consuming 30 grams or more of licorice daily for several weeks can cause severe side effects including high blood pressure, low potassium in the blood, weakness, paralysis, and occasionally brain damage in otherwise healthy people. In people who eat a lot of salt or have heart disease, kidney disease, or high blood pressure, as little as 5 grams per day can cause these problems.


Adrenal Cortex Extract : supplements/ingredientmono- 941-ADRENAL%20EXTRACT.aspx? activeIngredientId=941& activeIngredientName=ADRENAL% 20EXTRACT


the short answer is the WebMD lists no known interactions.


Probably way more than you wanted to know.


My take on it: it probably won’t hurt you, it may or may not help.

Tell Somebody!